ArticleBasic & clinical pharmacology & toxicology2023
Use of benzodiazepines and benzodiazepine-related drugs in the Nordic countries between 2000 and 2020.
Article in Basic & clinical pharmacology & toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Minor tranquillizers for short-term treatment of newly onset symptoms of anxiety and distress: a systematic review with network meta-analysis of randomized trials.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Benzodiazepine Prescription and Use in the Older Adults in Catalonia, Spain from 2018 to 2022: A Drug Utilization Study.Drugs & aging · 2026Article
- Fall-Risk-Increasing drugs and falls in community-dwelling older adults: a prospective cohort study in a single Danish municipality.European geriatric medicine · 2026Article
- Prevalence and Incidence of Oral Benzodiazepine Use in Hospitalized Surgical Patients: A Retrospective Cohort Study.Annals of surgery · 2026Article
- The incidence and clinical variables associated with new and new persistent benzodiazepine use after admission to internal medicine: a retrospective study.Scientific reports · 2026Article
- Observational
- Impact of policy measures targeting benzodiazepines and Benzodiazepine-related drugs in Lithuania: interrupted time series analysis.European journal of clinical pharmacology · 2026Article
- Trends in Sedative-Hypnotic Prescription Among Insomnia Patients: A Nationwide Cohort Study From 2010 to 2022 in Korea.Journal of Korean medical science · 2026Article
- Psychiatric health of Icelandic adults 40 years or older: A nationwide study of diagnoses, medications, and symptoms.PloS one · 2026Article
- The Incidence of Benzodiazepine and Benzodiazepine-Related Drug Use in People With and Without Parkinson's Disease-A Nationwide Cohort Study.Basic & clinical pharmacology & toxicology · 2025Article
- Trends in pharmacological prescriptions and polypharmacy for personality disorders: a 10-year cross-sectional analysis of naturalistic data.BMC psychiatry · 2025Article
- Trends in hypnotic drug use in depression 2007-2017: A Swedish population-based study.Journal of sleep research · 2025Article
- GPs' reflections on prescribing addictive hypnotics to older people: a qualitative study.BJGP open · 2024Article
- Trends in the use and nonmedical use of sedatives-hypnotics in the population aged 12 to 64 years in Taiwan: a comparative analysis of the national surveys in 2014 and 2018.BMC public health · 2024Article
- Prescription of benzodiazepines and antidepressants among Sami and non-Sami - How childhood violence shapes prescription patterns: the SAMINOR 2 questionnaire survey and the Norwegian prescription database.BMC public health · 2024Article
- Long-term benzodiazepine use and risk of labor market marginalization in Finland: A cohort study with 5-year follow-up.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Prescriptions of antidepressants and anxiolytics in France 2012-2022 and changes with the COVID-19 pandemic: interrupted time series analysis.BMJ mental health · 2024Article
- Use of Antidepressant and Anxiolytic Drugs in Scandinavian Countries between 2006 and 2021: A Prescription Database Study.Depression and anxiety · 2024Article
- Factors associated with long-term benzodiazepine and Z-drug use across the lifespan and 5-year temporal trajectories among incident users: a Swedish nationwide register-based study.European journal of clinical pharmacology · 2023Article
- Use of benzodiazepines and benzodiazepine-related drugs in the Nordic countries between 2000 and 2020.Basic & clinical pharmacology & toxicology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 6 countries.
Funding
Abstract
Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ-sedatives, BZ-hypnotics, and benzodiazepine-related drugs (BZRD) in adults (≥20 years) were obtained from nationwide registers in Denmark, Finland, Iceland, Norway, and Sweden, 2000-2020. Main measures were therapeutic intensity (TI:DDD/1000 inhabitants [inhab.]/day) and annual prevalence (users/1000 inhab./year). Overall, TI of BZ and related drugs decreased in all Nordic countries from 2004 to 2020. However, there were considerable differences between countries in TI. In 2020, the TI of BZ and related drugs ranged from 17 DDD/1000 inhab./day in Denmark to 93 DDD/1000 inhab./day in Iceland. BZRD accounted for 55-78% of BZ use in 2020, followed by BZ sedatives at 20-44%, BZ-hypnotics at <1-5%, and clonazepam at <1-2%. Annual prevalence of BZ use increased with age in all countries, and the highest annual prevalence was observed among people ≥80 years. Overall, the use of BZ and related drugs has decreased in all Nordic countries from 2004 to 2020, however, with considerable differences in their use between countries. The highest prevalence was observed among the oldest age groups-despite warnings against their use in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.