Evidence map›Paper›PMID 36314124›Full record

ArticleStroke2023

Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage.

Murad Megjhani, Miriam Weiss, Jenna Ford, Kalijah Terilli, Nick Kastenholz, Daniel Nametz, Soon Bin Kwon, Angela Velazquez, Sachin Agarwal, David J Roh and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. High risk and low incidence diseases: Aneurysmal subarachnoid hemorrhage.The American journal of emergency medicine · 2025
    Review
  11. Observational
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Individualized autoregulation-guided arterial blood pressure management in neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 5 countries.

Murad Megjhani *Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.ORCID 0000-0002-7613-6444
Miriam Weiss *Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).ORCID 0000-0001-8820-0805
Jenna FordDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.ORCID 0000-0001-7626-4780
Kalijah TerilliDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.ORCID 0000-0003-2198-5147
Nick KastenholzDepartment of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).
Daniel NametzDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.
Soon Bin KwonDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.ORCID 0000-0001-5076-0743
Angela VelazquezDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.
Sachin AgarwalDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.
David J RohDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.
Catharina Conzen-DilgerDepartment of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).ORCID 0000-0001-9979-5947
Walid AlbannaDepartment of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).
Michael VeldemanDepartment of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).ORCID 0000-0003-3648-6842
E Sander ConnollyDepartment of Neurosurgery (E.S.C.), Columbia University, NY.
Jan ClaassenDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.
Marcel AriesDepartment of Intensive Care, Maastricht University Medical Center, Maastricht University, the Netherlands (M.A.).ORCID 0000-0001-5327-1275
Gerrit A SchubertDepartment of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).ORCID 0000-0001-9135-6042
Soojin ParkDepartment of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.ORCID 0000-0002-3688-7307
Norwegian Womens Public Health Association · NORWTH Aachen University · DEKantonsspital Aarau · CHColumbia University · USMaastricht University Medical Centre · NL

Funding

RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
Characterize psychological and behavioral dimensions of cardiac arrest survivorship, and their association with 1-year mortality, cardiovascular disease risk, and health-related quality of lifeR01HL153311 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGARWAL, SACHIN · 2021 to 2024
$3.1M
Erythrocyte contribution to coagulopathy and cerebral oxygenation after intracerebral hemorrhageK23HL151901 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROH, DAVID · 2021 to 2025
$950k
Machine Learning to Optimize Management of Acute Hydrocephalus PatientsR21NS113055 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARK, SOOJIN · 2020 to 2020
$446k
NHLBI NIH HHS K23 HL151901NHLBI NIH HHS R01 HL153311NINDS NIH HHS R01 NS106014NINDS NIH HHS R21 NS113055
6 · The paper itself

Abstract

backgroundTargeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury. Brain tissue oxygenation (PbtO

methodsWe performed a retrospective analysis of a prospectively collected 2-center dataset of patients with aneurysmal subarachnoid hemorrhage with or without later diagnosis of delayed cerebral ischemia (DCI). CPPopt was calculated as the cerebral perfusion pressure (CPP) value corresponding to the lowest pressure reactivity index (moving correlation coefficient of mean arterial and intracranial pressure). The relationship of (hourly) deltaCPP (CPP-CPPopt) and PbtO

resultsOne hundred thirty-one patients were included with a median of 44.0 (interquartile range, 20.8-78.3) hourly CPPopt/PbtO2 datapoints. The regression plot revealed a nonlinear relationship between PbtO

conclusionsWe found a nonlinear relationship between PbtO

Indexed as

Brain Injuries, TraumaticBrain IschemiaSubarachnoid HemorrhageBrainCerebral InfarctionCerebrovascular CirculationHumansHypoxiaIntracranial PressureOxygenRetrospective StudiesOxygenbrainbrain injuries, traumatichyperemiainfarctionpartial pressure

Identifiers

PMID36314124
PMCPMC9780174
OpenAlexW4307771056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.