Trial reportCirculation. Heart failure2023
A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction.
2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 10 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Effects Caloric Restriction and Exercise Training in Patients With Heart Failure and a Normal Ejection Fraction
The Imaging Assessment of Sarcopenia Across the Heart Failure Spectrum
Who cites it
59 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta-Analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- The Impact of β-Blocker Therapy on Peak VOAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Pooled it
- Comparative Effects of 12 Exercise Modalities on Body Mass Index and Body Fat Percentage in Youth With Overweight or Obesity: A Systematic Review and Network Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Comparative effectiveness of exercise modalities and doses on carotid-femoral pulse wave velocity in adults: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review.Aging clinical and experimental research · 2025Pooled it
- Comparing exercise modalities during caloric restriction: a systematic review and network meta-analysis on body composition.Frontiers in nutrition · 2025Pooled it
- Comparison of the impact of exercise training combined with dietary intervention vs. dietary intervention alone in patients with obesity and metabolic syndrome-a systematic review.Frontiers in nutrition · 2025Pooled it
- Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis.Nutrients · 2024Pooled it
- Resistance is not futile: a systematic review of the benefits, mechanisms and safety of resistance training in people with heart failure.Heart failure reviews · 2024Pooled it
- Calcium Channel Blockade Versus β-Blockade for Hypertension in Heart Failure With Preserved Ejection Fraction: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Intervening on Calorie Intake or Eating Timing in Older Adults: Lessons Learned in the Healthy Aging and Late-Life Outcomes Randomized Controlled Pilot Trial.Clinical interventions in aging · 2025Trial
- Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.Nature medicine · 2025Trial
- Exercise, Nutrition and GLP-1 Medicines to Improve Body Weight and Muscle Function in Heart Failure with Preserved Ejection Fraction.Current heart failure reports · 2026Review
- Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF): Epidemiology, Mechanisms, and the Role of Lifestyle Modification.Journal of cardiovascular development and disease · 2026Review
- The Impact of Risk Factors and Comorbidities on Heart Failure in the Aging Population.International journal of molecular sciences · 2026Review
- Heart Failure with Preserved Ejection Fraction as a Multisystem Syndrome: A Mechanistically Anchored Endotype Framework for Precision Therapy.Journal of clinical medicine · 2026Review
- Glucagon-like Peptide-1 Therapy in Obesity-Related Heart Failure with Preserved Ejection Fraction: Mechanisms, Clinical Evidence, and Implications.Journal of clinical medicine · 2026Review
- Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.American journal of physiology. Heart and circulatory physiology · 2026Article
- Combined strength and aerobic training vs. aerobic training alone in patients with heart failure: A systematic review and meta-analysis.Journal of sport and health science · 2026Review
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Peter H BrubakerDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC (P.H.B.).ORCID 0000-0003-0918-4056
Barbara J NicklasSection on Gerontology and Geriatric Medicine, Department of Internal Medicine (B.J.N., D.K.H., W.M.L., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Denise K HoustonSection on Gerontology and Geriatric Medicine, Department of Internal Medicine (B.J.N., D.K.H., W.M.L., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.ORCID 0000-0002-3355-4304
W Gregory HundleySection on Gerontology and Geriatric Medicine, Department of Internal Medicine (B.J.N., D.K.H., W.M.L., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Haiying ChenDepartment of Biostatistical Sciences, Division of Public Health Sciences (H.C.), Wake Forest University School of Medicine, Winston-Salem, NC.
Anthony J A MolinaDepartment of Medicine, Division of Geriatrics, Gerontology and Palliative Care, University of California San Diego, La Jolla (A.J.A.M.).ORCID 0000-0002-5786-4622
W Mary LylesSection on Gerontology and Geriatric Medicine, Department of Internal Medicine (B.J.N., D.K.H., W.M.L., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.ORCID 0000-0002-2433-8853
Benjamin NelsonSection on Cardiology, Department of Internal Medicine (B.N., B.U., R.N., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Bharathi UpadhyaSection on Cardiology, Department of Internal Medicine (B.N., B.U., R.N., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Russell NewlandSection on Cardiology, Department of Internal Medicine (B.N., B.U., R.N., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Dalane W KitzmanSection on Gerontology and Geriatric Medicine, Department of Internal Medicine (B.J.N., D.K.H., W.M.L., D.W.K.), Wake Forest University School of Medicine, Winston-Salem, NC.
Funding
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4MREHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8MPepper OAIC Coordinating CenterU24AG059624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2018 to 2026
$6.0MExercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2MWake Forest Atrium HeartShare Clinical CenterU01HL160272 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2021 to 2026
$2.3MRepurposing of Metormin for Older Patients with HFpEFU01AG076928 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W, YADAV, HARIOM · 2022 to 2024
$2.3MNHLBI NIH HHS U01 HL160272NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NIA NIH HHS U01 AG076928NIA NIH HHS U24 AG059624
Abstract
backgroundWe have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O
methodsThis study is a randomized, controlled, single-blind, 20-week trial of RT+CR+AT versus CR+AT in 88 patients with chronic heart failure with preserved ejection fraction and body mass index (BMI) ≥28 kg/m
resultsSeventy-seven participants completed the trial. RT+CR+AT and CR+AT produced nonsignificant differences in weight loss: mean (95% CI): -8 (-9, -7) versus -9 (-11, -8;
conclusionsIn older obese heart failure with preserved ejection fraction patients, CR+AT produces large improvements in VO REGISTRATION: URL: https://ClincalTrials.gov; Unique identifier: NCT02636439.
Indexed as
CardiomyopathiesHeart FailureResistance TrainingAgedCaloric RestrictionExerciseHumansObesitySingle-Blind MethodStroke Volumediastolic heart failureelderlyexerciseheart failureobesityresistance training
Identifiers
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Registered trials
NCT02636439ClinicalTrials.gov
NCT05888688ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.