ReviewFrontiers in medicine2022
Heart rate variability: A biomarker of frailty in older adults?
Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Effects of Acute Photobiomodulation on Heart Rate Variability in Physically Active Individuals: A Randomized and Controlled Clinical Trial.Journal of biophotonics · 2026Trial
- Circadian rhythm of heart rate variability in tropical horses: age-associated autonomic alterations and environmental air pollution effects in an urban field setting.Veterinary world · 2026Article
- Predicting the Risk of Cardiovascular Diseases in the Elderly Based on Clinical Data and Heart Rate Variability Using Machine Learning.Journal of clinical medicine · 2026Article
- Life satisfaction mediates advanced maternal age at childbirth and frailty across cohorts.iScience · 2026Article
- Effects of a 6-Week Intermittent Hypoxia-Hyperoxia Exposure Program on Blood Pressure, Respiratory Function, Cardiac Autonomic Nervous Activity and CRP Levels in Older Adults: A Randomized Clinical Trial.Sports (Basel, Switzerland) · 2026Article
- Assessment of Frailty Status and Its Association with Heart Rate Variability and Body Composition Among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Journal of frailty, sarcopenia and falls · 2025Article
- Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults.Nature communications · 2025Article
- Article
- Heart Rate Variability: Marker of the Impact of Cardiovascular Disease on Intrinsic Capacity in Older Adults.Journal of clinical medicine · 2025Article
- Review
- Phenome-wide associations of sleep characteristics in the Human Phenotype Project.Nature medicine · 2025Article
- Heart rate variability as a digital biomarker for frailty in cardiovascular patients.The Journal of frailty & aging · 2025Article
- Article
- A Real-Time Web-Based Intervention with a Multicomponent Group-Based Program for Older Adults: Single-Arm Feasibility Study.Healthcare (Basel, Switzerland) · 2024Article
- Assessing Cardiovascular Risk in Geriatric Patients Without Atherosclerotic Cardiovascular Disease.Journal of clinical medicine · 2024Article
- Ability of Heart Rate Recovery and Gait Kinetics in a Single Wearable to Predict Frailty: Quasiexperimental Pilot Study.JMIR formative research · 2024Article
- Remote fitness assessment in younger and middle-aged to older adults: a comparison between laboratory- and videoconference-based assessment of selected measures of physical and cognitive fitness.BMC sports science, medicine & rehabilitation · 2024Article
- Association between arteriosclerosis, hemodynamic indices, and the risk of falls: receiver operating characteristic curve analysis for different indices in older individuals.Frontiers in medicine · 2024Article
- Influence of an inspiratory muscle fatigue protocol on older adults on respiratory muscle strength and heart rate variability. A randomized controlled trial.Frontiers in neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is a state of critical loss of physiological complexity resulting in greater vulnerability to stressors and has been characterized as a debility syndrome in the older adult. Changes in functional capacity and the cardiovascular system during aging are the most significant and relevant for this population, including the clinically healthy. In this sense, this review aims to investigate methods to monitor the performance of older adults, such as heart rate variability and verify how it can be related to frailty. It contributes to understanding that the changes in heart variability can be a marker for frailty in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.