Evidence map›Paper›PMID 36313942›Full record

ArticleAdvanced nanobiomed research2022

Characterizing Lipid-Coated Mesoporous Silica Nanoparticles as CD169-Binding Delivery System for Rilpivirine and Cabotegravir.

Han Zang, Josiane Fofana, Fangda Xu, Sarah B Nodder, Suryaram Gummuluru, Björn M Reinhard

Open access · goldAbstract read
In one paragraph

Article in Advanced nanobiomed research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Exploring CD169Vaccines · 2025
    Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Han ZangDepartment of Chemistry and The Photonics Center, Boston University, Boston MA 02215, United States.
Josiane FofanaDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, United States.
Fangda XuDepartment of Chemistry and The Photonics Center, Boston University, Boston MA 02215, United States.
Sarah B NodderDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, United States.
Suryaram GummuluruDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, United States.
Björn M ReinhardDepartment of Chemistry and The Photonics Center, Boston University, Boston MA 02215, United States.
Boston University · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
RESEARCH TRAINING IN IMMUNOLOGYT32AI007309 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GUMMULURU, SURYARAM · 1988 to 2024
$7.4M
GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic TissuesR01AI132111 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GUMMULURU, SURYARAM, REINHARD, BJOERN MARKUS · 2018 to 2022
$2.7M
Advanced laser scanning confocal microscope for multiple usersS10OD024993 · OD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2018 to 2018
$448k
NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI132111NIAID NIH HHS T32 AI007309NIH HHS S10 OD024993
6 · The paper itself

Abstract

Herein, lipid-coated mesoporous silica nanoparticles (LMSN) are investigated as biomimetic delivery vehicle for two antiretroviral compounds (ARVs), rilpivirine (RPV) and cabotegravir (CAB). Monosialodihexosylganglioside (GM3) is incorporated into the membrane to facilitate LMSN binding to CD169 (Siglec-1)-expressing myeloid cells, that are predominantly expressed in secondary lymphoid tissues

Indexed as

antiretroviral drugsdrug deliverylipid-coated mesoporous silica nanoparticles

Identifiers

PMID36313942
PMCPMC9610980
OpenAlexW4220665694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.