Evidence map›Paper›PMID 36313784›Full record

ArticleFrontiers in endocrinology2022

Sex-specific regulation of IL-10 production in human adipose tissue in obesity.

Narmadha Subramanian, Beatriz Tavira, Kaisa Hofwimmer, Beate Gutsmann, Lucas Massier, Julie Abildgaard, Anders Juul, Mikael Rydén, Peter Arner, Jurga Laurencikiene

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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  9. Estrogen: the forgotten player in metaflammation.Frontiers in pharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Narmadha SubramanianLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Beatriz TaviraLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Kaisa HofwimmerLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Beate GutsmannMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Lucas MassierLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Julie AbildgaardCentre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anders JuulDepartment of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Mikael RydénLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Peter ArnerLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Jurga LaurencikieneLipid laboratory, Unit of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SECopenhagen University Hospital · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity-associated metabolic complications display sexual dimorphism and can be impacted by cytokines. We previously showed that interleukin-10 (IL-10) was upregulated in white adipose tissue (WAT) of obese women with type 2 diabetes (T2D). Whether this pertains to men is unknown. The aim of this study was to compare the impact of obesity and T2D on WAT IL-10 levels in men versus women. Methods: Plasma and subcutaneous WAT biopsies were obtained from 108 metabolically well-characterized individuals. WAT Results: Obese women with T2D showed increased Conclusion: WAT IL-10 levels are higher in women with obesity and T2D, but not in men and this effect is primarily attributed to obesity

Indexed as

Diabetes Mellitus, Type 2Interleukin-10Adipose TissueAdipose Tissue, WhiteFemaleHumansMaleObesityInterleukin-10adiposeIL-10macrophagesmenobesitysex-specificwomen

Identifiers

PMID36313784
PMCPMC9606404
OpenAlexW4306155667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.