ArticleFrontiers in endocrinology2022
Lack of placental neurosteroid alters cortical development and female somatosensory function.
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Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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0cells of the map it votes in
15citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Placental Insulin-like Growth Factor 1 Insufficiency Drives Neurodevelopmental Disorder-Relevant Behavioral Changes with Sex-Specific Vulnerabilities.bioRxiv : the preprint server for biology · 2026Article
- Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity.Developmental psychobiology · 2026Article
- Comprehensive Analysis of the Placenta-Cortex Transcriptomic Database Reveals a Neuroactive Ligand-Receptor Dysregulation After Prenatal Alcohol Exposure.International journal of molecular sciences · 2026Article
- Placental Igf1 overexpression sex-specifically impacts mouse placenta structure, altering offspring striatal development and behavior.Experimental neurology · 2025Article
- Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy.Clinical epigenetics · 2025Article
- Microglia alter sex-specific cerebellar myelination following placental hormone loss.Nature communications · 2025Article
- A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution.Journal of neuroendocrinology · 2025Review
- Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth.Frontiers in cellular neuroscience · 2025Article
- Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health.International journal of molecular sciences · 2024Review
- A spatiotemporal transcriptomic atlas of mouse placentation.Cell discovery · 2024Article
- Impact of maternal immune activation and sex on placental and fetal brain cytokine and gene expression profiles in a preclinical model of neurodevelopmental disorders.Journal of neuroinflammation · 2024Article
- Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP.Journal of neuroendocrinology · 2023Article
- Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Dana BakalarCenter for Neuroscience Research, Children's Research Institute, Children's National Health System, Washington, DC, United States.
Jiaqi J O'ReillyDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Helene LacailleDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Jacquelyn SalzbankDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Jacob EllegoodMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada.
Jason P LerchWellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Toru SasakiCenter for Neuroscience Research, Children's Research Institute, Children's National Health System, Washington, DC, United States.
Yuka ImamuraDepartment of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA, United States.
Kazue Hashimoto-ToriiCenter for Neuroscience Research, Children's Research Institute, Children's National Health System, Washington, DC, United States.
Claire-Marie VacherDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Anna A PennDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Columbia University · USChildren's National · USHospital for Sick Children · CAMorgan Stanley Children's Hospital · USPennsylvania State University · USWellcome Centre for Integrative Neuroimaging · GB
Funding
Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI LAUREN KENWORTHY · 2021 to 2026
$9.3MResearch_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9MNovel Roles of Placental Allopregnanolone in Brain Development and InjuryR01HD092593 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANNA A PENN · 2017 to 2026
$3.9MADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0MPlacental Allopregnanolone is Essential for Development of Cortical GABAergic SignalingF31HD098886 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI O'REILLY, JULIA JIAQI · 2019 to 2020
$74kNICHD NIH HHS F31 HD098886NICHD NIH HHS P50 HD105328NICHD NIH HHS R01 HD092593NICHD NIH HHS U54 HD090257NINDS NIH HHS T32 NS064928
Abstract
Placental endocrine function is essential to fetal brain development. Placental hormones include neurosteroids such as allopregnanolone (ALLO), a regulator of neurodevelopmental processes
Indexed as
NeurosteroidsAdolescentFemaleHumansInfant, NewbornInfant, PrematureMalePlacentaPregnancyPregnanoloneReceptors, GABA-ANeurosteroidsPregnanoloneReceptors, GABA-Aallopregnanolone (3α,5α-THP)GABAA receptor (GABAAR)neuroplacentologyplacentapostmortem human brainpreterm birthsomatosensory cortex (S1)
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.