ArticleFrontiers in endocrinology2022
Risk of preeclampsia by gestational weight gain in women with varied prepregnancy BMI: A retrospective cohort study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Association between pre-pregnancy BMI and preterm birth in Chinese women: a retrospective study.Annals of medicine · 2026Article
- Article
- Preliminary Evidence of the Association Between Binge Eating and Preeclampsia in Pregnant U.S. Military Active-Duty Service Women.The International journal of eating disorders · 2026Article
- The effect of maternal pre-pregnancy body mass index on hypertensive disorders of pregnancy (HDP): a systematic review and dose-response meta-analysis of cohort studies involving 50 million pregnancies.EClinicalMedicine · 2025Article
- The construction and validation of a prediction model of hypertensive disease in pregnancy.Scientific reports · 2025Article
- Relationship between prepregnancy BMI and gestational weight gain(GWG) with preeclampsia: a study based on restricted cubic spline.BMC pregnancy and childbirth · 2025Article
- Elucidating shared genetic association between female body mass index and preeclampsia.Communications biology · 2025Article
- Article
- Polymorphism rs259983 of the Zinc Finger Protein 831 Gene Increases Risk of Superimposed Preeclampsia in Women with Gestational Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Investigation and Comparison of Maternal Pre-Pregnancy Body Mass Index Coupled with Gestational Weight Gain on Maternal-Fetal Complications Based on US and Chinese Guidelines: A Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Association between migraine and pre-eclampsia among pregnant women: a single hospital-based case-control study in India.BMC pregnancy and childbirth · 2024Article
- The association between diet quality index-international and dietary diversity score with preeclampsia: a case-control study.BMC women's health · 2024Article
- Early HbA1c Levels as a Predictor of Adverse Obstetric Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Gestational weight gain of multiparas and risk of primary preeclampsia: a retrospective cohort study in Shanghai.Clinical hypertension · 2023Article
- Assessment of maternal nutritional status in early pregnancy and gestational weight gain in selected areas in the Philippines: A pilot study.Women's health (London, England)Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Despite the important clinical significance, limited data on the joint contribution of prepregnancy body mass index (BMI) and gestational weight gain (GWG) to preeclampsia, the second leading cause of maternal mortality worldwide. This study aimed to estimate the risk of preeclampsia by GWG among women with varied prepregnancy BMI. Methods: We conducted a retrospective cohort study using data of 117 738 singleton pregnant women aged 18-49 years from 150 maternity hospitals in China between 2015 and 2018. GWG was calculated as the measured weight at the time of preeclampsia assessment minus prepregnancy weight; GWG velocity was calculated as the GWG divided by the gestational age at weighing. The non-linear associations of GWG with preeclampsia were examined by restricted cubic spline regression analysis according to prepregnancy BMI. The association of the GWG categories with preeclampsia was further examined by performing robust Poisson regression stratified by the prepregnancy BMI categories. Results: Among participants, 2426 (2.06%) were diagnosed with preeclampsia. Compared to women with normal BMI, those who were overweight and obese had 1.92- fold (95%CI, 1.73-2.14) and 5.06- fold (95%CI, 4.43-5.78) increased risks for preeclampsia, respectively. The association of GWG velocity with preeclampsia was presented as a J-shaped curve with the varied inflexion point (where the rate of preeclampsia was 2%), which was 0.54, 0.38, and 0.25 kg/week in women with normal BMI, overweight, and obesity, respectively; a steep risk rise was observed along with GWG velocity beyond the inflexion points. The overall adjusted relative risk for preeclampsia was calculated among women with the different GWG categories of GWG. Conclusions: The findings highlight that high prepregnancy BMI and exceed GWG contributed to increased risk of preeclampsia with a superimposed effect and underscore the need to optimize the recommendations for GWG for women with different prepregnancy BMI.
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