Evidence map›Paper›PMID 36313640›Full record

ArticleFrontiers in oncology2022

Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer.

Wenjuan Tian, Zhaodong Ji, Jingshu Wang, Jiao Meng, Rui Bi, Yulan Ren, Boer Shan, Gong Yang, Huaying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Functions, interactions and prognostic role ofJournal of gynecologic oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenjuan TianDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhaodong JiDepartment of Clinical Laboratory, Huashan Hospital, Fudan University, Shanghai, China.
Jingshu WangCentral Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Jiao MengDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Rui BiDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Yulan RenDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Boer ShanDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Gong YangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Huaying WangDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene ( Methods: Results: In addition to previously reported P286R and V411L, R375Q and P452L were identified as novel, and deleterious Conclusion: We characterized the of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene and identified P286R, V411L, R375Q, and P452L as pathogenic

Indexed as

3’-5’-ExonucleaseDNA polymerase epsilonDNA replicationendometrial cancerhotspot exonuclease domain mutations

Identifiers

PMID36313640
PMCPMC9596989

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.