Evidence map›Paper›PMID 36313618›Full record

ArticleFrontiers in cellular neuroscience2022

Artificial sleep-like up/down-states induce synaptic plasticity in cortical neurons from mouse brain slices.

Gai-Linn Kay Besing, Emily Kate St John, Cobie Victoria Potesta, Martin J Gallagher, Chengwen Zhou

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gai-Linn Kay BesingDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Emily Kate St JohnDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Cobie Victoria PotestaDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Martin J GallagherDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Chengwen ZhouDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Subcortical Nodes Within Epileptic Network Control the Cortical Disfacilitation to Prompt Seizure Onset in IGE Mouse ModelR01NS107424 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHOU, CHENGWEN · 2018 to 2022
$2.0M
Impaired homeostatic potentiation of GABAergic currents initiates seizuresR21NS096483 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GALLAGHER, MARTIN J, MACDONALD, ROBERT LOUDEN · 2016 to 2017
$435k
BLRD VA I01 BX005316NICHD NIH HHS P50 HD103537NINDS NIH HHS R01 NS107424NINDS NIH HHS R21 NS096483
6 · The paper itself

Abstract

During non-rapid eye movement (NREM) sleep, cortical neuron activity alternates between a depolarized (firing, up-state) and a hyperpolarized state (down-state) coinciding with delta electroencephalogram (EEG) slow-wave oscillation (SWO, 0. 5-4 Hz)

Indexed as

brain sliceshomeostatic synaptic plasticitysleepup/down-statewhole-cell recordings

Identifiers

PMID36313618
PMCPMC9615418

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.