ArticleFrontiers in cell and developmental biology2022
The uniformity and stability of cellular mass density in mammalian cell culture.
Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
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- Inertial sensing of water content in tumor spheroids.Science advances · 2026Article
- How does cytoplasmic crowding affect reaction rates?Molecular cell · 2026Review
- Optical Measurement of the Mass Density of Biological Samples.ACS photonics · 2025Article
- Ptychographic analysis of human bone marrow-derived mesenchymal stem cell morphology: The impact of cell senescence.Journal of microscopy · 2025Article
- High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples.Nature biomedical engineering · 2025Article
- Normalized Raman Imaging for Studies of Tissue Physiology of the Kidney.bioRxiv : the preprint server for biology · 2025Article
- Cells prioritize the regulation of cell mass density.Science advances · 2025Article
- Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes.Nature communications · 2025Article
- Spatio-Temporal Dynamics of MBulletin of mathematical biology · 2025Article
- Underestimated role of macromolecular crowding in bioengineeredMaterials today. Bio · 2025Article
- Liposome-EncapsulatedACS synthetic biology · 2025Article
- Membrane nanodomains to shape plant cellular functions and signaling.The New phytologist · 2025Review
- Measuring Molecular Mass Densities at Subcellular Resolution Using Optical Diffraction Tomography.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells.Nature structural & molecular biology · 2024Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- Single-cell laser emitting cytometry for label-free nucleolus fingerprinting.Nature communications · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell dry mass is principally determined by the sum of biosynthesis and degradation. Measurable change in dry mass occurs on a time scale of hours. By contrast, cell volume can change in minutes by altering the osmotic conditions. How changes in dry mass and volume are coupled is a fundamental question in cell size control. If cell volume were proportional to cell dry mass during growth, the cell would always maintain the same cellular mass density, defined as cell dry mass dividing by cell volume. The accuracy and stability against perturbation of this proportionality has never been stringently tested. Normalized Raman Imaging (NoRI), can measure both protein and lipid dry mass density directly
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