ArticleFrontiers in cell and developmental biology2022
SEC5 is involved in M2 polarization of macrophages
Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- ESRRG downregulation in early spontaneous abortion induces mitochondrial damage, leading to impaired trophoblast function.Annals of medicine · 2026Article
- The role and underlying mechanism of FABP4 dysregulation mediated by m6A modification in unexplained recurrent spontaneous abortion.Journal of translational medicine · 2026Article
- Progesterone in recurrent pregnancy loss: from controversial efficacy to mechanism-based patient stratification.Frontiers in pharmacology · 2026Review
- Article
- Targeting Decidual Macrophage Polarization through JNK Signaling Pathway Inhibition Alleviates Adverse Pregnancy Outcomes in Early Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Identification of potential hub genes associated with recurrent miscarriage through combined transcriptomic and proteomic analysis.Biomolecules & biomedicine · 2025Article
- Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy.Reproductive biology and endocrinology : RB&E · 2025Review
- Decidual macrophage: a reversible role in immunotolerance between mother and fetus during pregnancy.Archives of gynecology and obstetrics · 2024Review
- Increased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERα/NLRP3 pathway and induces adverse pregnancy outcomes in mice.Cell death discovery · 2024Article
- Role of Immune Inflammation in Recurrent Spontaneous Abortions.Journal of inflammation research · 2024Article
- Role of protein post-translational modifications in unexplained recurrent pregnancy loss.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesReview
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decidual macrophages (dMϕs) play critical roles in the establishment of microhomeostasis at the maternal-fetal interface during pregnancy. Impaired macrophage polarization during early pregnancy is associated with recurrent spontaneous abortion (RSA). In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation
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