Evidence map›Paper›PMID 36313496›Full record

ArticleFrontiers in neurology2022

Presence of anti-nuclear antibody associated with worse clinical outcomes of anti-NMDAR encephalitis.

Chunyan Lei, Yongyu Li, Haijiang Li, Xiaoyan Zhu, Wen Jiang, Xiaolong Chang

Abstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunyan LeiDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yongyu LiDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Haijiang LiDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiaoyan ZhuDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Wen JiangDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiaolong ChangDepartment of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Systemic autoantibodies are important for the diagnosis of autoimmune diseases, but their roles in anti- Methods: Systemic autoantibodies were evaluated in 64 patients with anti-NMDAR encephalitis and 14 patients with autoimmune encephalitis with other forms. Then, according to systemic autoantibodies, patients with anti-NMDAR encephalitis were divided into an anti-nuclear antibody (ANA) positive group and an ANA negative group. The clinical outcome was assessed by a modified Rankin score at 12 months after the disease onset. Results: A total of 64 patients with anti-NMDAR encephalitis were enrolled, of which 28.13% (18/64) were positive for ANA. The titers of a positive anti-NMDAR antibody in CSF ( Conclusion: ANA was prevalent in patients with anti-NMDAR encephalitis, and associated with a worse prognosis and impaired neurological recovery.

Indexed as

anti-N-methyl-D-aspartate receptor encephalitisanti-nuclear antibodyautoantibodiesclinical characteristicprognosis

Identifiers

PMID36313496
PMCPMC9596912

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