Evidence map›Paper›PMID 36313452›Full record

ArticleFrontiers in genetics2022

Genetic polymorphisms of toll-like receptors in leprosy patients from southern Brazil.

Priscila Saamara Masin, Hugo Alves Visentin, Laíse Nayana Sala Elpidio, Ana Maria Sell, Lorena Visentainer, Quirino Alves De Lima Neto, Joana Maira Valentini Zacarias, Patrícia Couceiro, Andressa Higa Shinzato, Manuel Santos Rosa and 2 more

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In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Priscila Saamara MasinImmunology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Hugo Alves VisentinImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Laíse Nayana Sala ElpidioImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Ana Maria SellImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Lorena VisentainerDepartment of Medicine, Faculty of Medicine Science, Campinas State University, Campinas, SP, Brazil.
Quirino Alves De Lima NetoImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Joana Maira Valentini ZacariasImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Patrícia CouceiroImmunology and Oncology Laboratory, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.
Andressa Higa ShinzatoImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.
Manuel Santos RosaImmunology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Paulo Rodrigues-SantosImmunology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Jeane Eliete Laguila VisentainerImmunogenetics Laboratory, Department of Basic Health Sciences, Post-Graduation Program in Biosciences and Phisiophatology, Maringá State University, Maringá, PR, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leprosy is a chronic disease and also a global health issue, with a high number of new cases per year. Toll-like receptors can respond to mycobacterial molecules in the early stage of infection. As important components of the innate immune response, alterations in genes coding for these receptors may contribute to susceptibility/protection against diseases. In this context, we used a case-control study model (183 leprosy cases vs. 185 controls) to investigate whether leprosy patients and the control group, in southern Brazil, have different frequencies in

Indexed as

innate immunity responseleprosyTLR1TLR2toll-like receptors (TLR)

Identifiers

PMID36313452
PMCPMC9596761

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.