Evidence map›Paper›PMID 36313381›Full record

ArticleFrontiers in pharmacology2022

Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.

Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Analytical cellular pathology (Amsterdam) · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dan HuangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.
Chaoqun SunDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Min ChenDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Shuyou BaiDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Xuanna ZhaoDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Weiming WangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.
Kang GengState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.
Wenbo HuangState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.
Tingting ZhaoState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.
Bin WuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Guilin ZhangGuangdong Keguanda Pharmaceutical Technology Co Ltd, Guangzhou, China.
Dong WuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Youhua XuState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Airway inflammation and remodeling are critical pathological changes in asthma, and macrophage activation plays a vital role in this process. Sirtuin 1 (SIRT1) reduces airway inflammation by affecting macrophages in asthma. This study aimed to investigate the potential benefit and underlying mechanism of the SIRT1 agonist bergenin as a treatment for asthma. We performed

Indexed as

asthmabergeninmacrophageNF-κBSIRT1

Identifiers

PMID36313381
PMCPMC9606584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.