Evidence map›Paper›PMID 36313100›Full record

ArticleFrontiers in nutrition2022

Quercetin improves lacrimal gland function through its anti-oxidant actions: Evidence from animal studies, and a pilot study in healthy human volunteers.

Takaaki Inaba, Mayumi Ohnishi-Kameyama, Ying Liu, Yasuhisa Tanaka, Masuko Kobori, Shusaku Tamaki, Tomotaka Ito, Kazunari Higa, Jun Shimazaki, Kazuo Tsubota

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Extract fromNutrients · 2024
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Potential New Target for Dry Eye Disease-Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Review
  14. Method for Collection of Tear Fluid for Evaluation Its Antioxidant Properties.Bulletin of experimental biology and medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takaaki InabaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Mayumi Ohnishi-KameyamaFood Research Institute, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Ying LiuDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Yasuhisa TanakaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Masuko KoboriFood Research Institute, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Shusaku TamakiDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Tomotaka ItoDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Kazunari HigaDepartment of Ophthalmology/Cornea Center, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
Jun ShimazakiDepartment of Ophthalmology/Cornea Center, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
Kazuo TsubotaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-oxidant properties of polyphenols have been gaining medical attention as a preventive factor against aging and/or lifestyle diseases. In this study, we examined the anti-oxidant activity of quercetin improved tear function through its effects on the lacrimal gland in mice and humans. Six week-old diabetic mice, a model for decreased tear production, were fed for 12 weeks

Indexed as

anti-oxidantdry eyelacrimal glandquercetintear secretion

Identifiers

PMID36313100
PMCPMC9599396

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.