Evidence map›Paper›PMID 36313089›Full record

ArticleFrontiers in nutrition2022

Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up.

Estefanía Diéguez, Ana Nieto-Ruiz, Cristina Martín-Pérez, Natalia Sepúlveda-Valbuena, Florian Herrmann, Jesús Jiménez, Roser De-Castellar, Andrés Catena, José Antonio García-Santos, Mercedes G Bermúdez and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02094547 (Evaluación Del Efecto de Una Nueva fórmula Infantil Con Ingredientes específicos Sobre el Desarrollo Neurocognitivo e inmunológico en Lactantes), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02094547 naunknown statusnot on this map

Evaluación Del Efecto de Una Nueva fórmula Infantil Con Ingredientes específicos Sobre el Desarrollo Neurocognitivo e inmunológico en Lactantes

TypeinterventionalSponsorLaboratorios OrdesaRan2010 to 2020Enrolled220ConditionsInfant DevelopmentArmsNew infant formula, Standard infant formula, Breastfeeding
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Estefanía DiéguezDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.
Ana Nieto-RuizDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.
Cristina Martín-PérezPsychology Department, Faculty of Education, University of Valladolid, Segovia, Spain.
Natalia Sepúlveda-ValbuenaNutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia.
Florian HerrmannDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.
Jesús JiménezOrdesa Laboratories, S.L., Sant Boi de Llobregat, Spain.
Roser De-CastellarOrdesa Laboratories, S.L., Sant Boi de Llobregat, Spain.
Andrés CatenaDepartment of Experimental Psychology, School of Psychology, University of Granada, Granada, Spain.
José Antonio García-SantosDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.
Mercedes G BermúdezDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.
Cristina CampoyDepartment of Paediatrics, School of Medicine, University of Granada, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breastfeeding (BF) is the gold standard in infant nutrition; knowing how it influences brain connectivity would help understand the mechanisms involved, which would help close the nutritional gap between infant formulas and breast milk. We analyzed potential long-term differences depending on the diet with an experimental infant formula (EF), compared to a standard infant formula (SF) or breastfeeding (BF) during the first 18 months of life on children's hypothalamic functional connectivity (FC) assessed at 6 years old. A total of 62 children participating in the COGNIS randomized clinical trial (Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02094547) were included in this study. They were randomized to receive an SF ( Clinical trial registration: https://www.clinicaltrials.gov/, identifier NCT02094547.

Indexed as

eating behaviorhypothalamuslong chain polyunsaturated fatty acids (LC-PUFAs)mean glucose levelsmilk fat globule membrane (MFGM)neuroimagingsynbiotics

Identifiers

PMID36313089
PMCPMC9597646

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.