Evidence map›Paper›PMID 36312952›Full record

ArticleFrontiers in microbiology2022

BosR: A novel biofilm-specific regulator in

Melanie Dostert, Corrie R Belanger, Lucas Pedraz, Morgan A Alford, Travis M Blimkie, Reza F Falsafi, Manjeet Bains, Bhavjinder Kaur Dhillon, Cara H Haney, Amy H Lee and 1 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melanie DostertCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Corrie R BelangerCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Lucas PedrazCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Morgan A AlfordCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Travis M BlimkieCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Reza F FalsafiCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Manjeet BainsCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Bhavjinder Kaur DhillonCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Cara H HaneyDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Amy H LeeCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Robert E W HancockCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilms are the most common cause of bacterial infections in humans and notoriously hard to treat due to their ability to withstand antibiotics and host immune defenses. To overcome the current lack of effective antibiofilm therapies and guide future design, the identification of novel biofilm-specific gene targets is crucial. In this regard, transcriptional regulators have been proposed as promising targets for antimicrobial drug design. Therefore, a Transposon insertion sequencing approach was employed to systematically identify regulators phenotypically affecting biofilm growth in

Indexed as

biofilm defectsbiofilm regulationbiofilmsgenomicsone-component transcriptional regulatorsPseudomonas aeruginosaTnSeqtranscriptional regulators

Identifiers

PMID36312952
PMCPMC9611778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.