ReviewJournal of International Society of Preventive & Community Dentistry
Estimation of Serum, Salivary, and Gingival Crevicular Uric Acid of Individuals With and Without Periodontal Disease: A Systematic Review and Meta-analysis.
Review in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Low salivary uric acid levels and periodontitis: New insights and implications for clinical practice.World journal of clinical cases · 2025Article
- Unraveling the enigma of salivary uric acid in periodontitis: Independent association, mechanistic insights, and future trajectories.World journal of clinical cases · 2025Article
- Low salivary uric acid levels are independently associated with periodontitis.World journal of clinical cases · 2025Article
- Impact of oral conditions on salivary biochemical parameters in individuals with substance use disorder: a cross-sectional study.Brazilian oral research · 2025Article
- Periodontal disease and serum uric acid levels in the absence of metabolic syndrome: is there a link? A study on a sample of Cameroonian adults.BMC oral health · 2024Article
- Relationship between Carotid Intima-Media Thickness, Periodontal Disease, and Systemic Inflammation Biomarkers in an Adult Population.Biomedicines · 2024Article
- The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry.Journal of personalized medicine · 2023Review
- Salivary Biomarkers in Periodontitis Post Scaling and Root Planing.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Uric acid (UA) levels in serum, salivary, and gingival crevicular fluid (GCF) may be associated with periodontal diseases. Hence, this study aimed to estimate the UA concentration in serum, saliva, and GCF of periodontal disease and non-periodontal disease subjects by conducting a systematic review and a meta-analysis of the reported studies. Materials and Methods: A review of the available literature was searched in the electronic databases of PubMed, Cochrane, Science Direct, and EBSCO for the relevant publications. All the related case-control, cross-sectional, and cohort studies reporting the UA levels in the blood, salivary, and GCF between periodontal disease patients and healthy controls were analyzed. Significant heterogeneity was observed in the studies. Hence, a continuous random-effects model was used. The findings are described in forest plots with the point estimations and 95% confidence interval (CI). A value of Results: Of the initial 166 study titles screened, 14 reported papers were eligible for quantitative review. The subgroup analysis of serum UA revealed a mean difference of 0.299 (95% CI: 0.029-0.569, Conclusion: The current review suggests an increase in the serum UA levels in periodontal disease than in healthy controls. Contrarily, the salivary UA levels decreased in periodontal disease patients. It is unknown why UA levels are opposite in the blood and saliva of periodontal disease patients requiring further explanation.
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