ReviewWorld journal of clinical cases2022
Liver transplantation for hepatocellular carcinoma: Historical evolution of transplantation criteria.
Review in World journal of clinical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Advances in liver transplantation for hepatic malignancies.Hepatic oncology · 2026Review
- A Leakage-Free Survival-Modelling Benchmark for Hepatocellular Carcinoma Recurrence After Liver Transplantation: Nested Cross-Validation Against the Milan Criteria.Bioengineering (Basel, Switzerland) · 2026Article
- Monitoring Inflammatory Markers and Anti-α-Gal Antibodies in Liver Transplant Recipients: Implications for Infection and Rejection.Diagnostics (Basel, Switzerland) · 2026Article
- Hepatocellular Carcinoma and the Role of Liver Transplantation: An Update and Review.Journal of clinical and translational hepatology · 2025Review
- Hemodynamic Monitoring During Liver Transplantation for Patients on Perioperative Extracorporeal Membrane Oxygenation (ECMO) Support: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Evolving Indications for Liver Transplantation for Hepatocellular Carcinoma Following the Milan Criteria.Cancers · 2025Article
- Are Ki-67 and Procalcitonin Expression Levels Useful in Predicting the Biological Behavior of Hepatocellular Carcinoma After Liver Transplantation?Journal of clinical medicine · 2024Article
- Article
- New Developments and Challenges in Liver Transplantation.Journal of clinical medicine · 2023Review
- A new method for predicting the microvascular invasion status of hepatocellular carcinoma through neural network analysis.BMC surgery · 2023Article
- Review
- Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations.World journal of clinical cases · 2023Article
- Impact of apparent diffusion coefficient on prognosis of early hepatocellular carcinoma: a case control study.BMC surgery · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver transplantation (LT) for hepatocellular carcinoma is still a hot topic, and the main factor that is associated with the success of treatment is to determine the patients who will benefit from LT. Milan criteria have been defined 25 years ago and still is being used for patient selection for LT. However, in living donor LT, the Milan criteria is being extended. Current criteria for patient selection do not only consider morphologic characteristics such as tumor size and number of tumor nodules but also biologic markers that show tumor aggressiveness is also being considered. In the present review article, we have summarized all the criteria and scoring systems regarding LT for hepatocellular carcinoma. All criteria have 5-year overall survival rates that were comparable to the Milan Criteria and ranged between 60%-85%. On the other hand, it was seen that the recurrence rates had increased as the Milan criteria were exceeded; the 5-year recurrence rates ranged between 4.9% to 39.9%. Treatment of hepatocellular carcinoma needs a multidisciplinary approach. Ideal selection criteria are yet to be discovered. The same is true for treatment modalities. The goal will be achieved by a harmonic interplay between basic science researchers and clinicians.
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