Evidence map›Paper›PMID 36312461›Full record

ArticleBiomedical journal of scientific & technical research2019

Estrogen Sulfotransferase Induction Inhibits Breast Cancer Cell Line MCF-7 Proliferation.

Weiyu Jiang, Zhao Dai, Guangping Chen

Open access · diamondAbstract read
In one paragraph

Article in Biomedical journal of scientific & technical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Weiyu JiangDepartment of Physiological Sciences, Center for Veterinary Health Sciences, USA.
Zhao DaiDepartment of Physiological Sciences, Center for Veterinary Health Sciences, USA.
Guangping ChenDepartment of Physiological Sciences, Center for Veterinary Health Sciences, USA.
American Physiological Society · US

Funding

Mechanisms and Functions of Human SulfotransferasesR01GM078606 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHEN, GUANGPING · 2006 to 2009
$1.1M
ACTIVE SITE STUDIES OF HUMAN SULFOTRANSFERASESR01GM059873 · NIGMS · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · PI CHEN, GUANGPING · 2000 to 2003
$759k
NIGMS NIH HHS R01 GM059873NIGMS NIH HHS R01 GM078606
6 · The paper itself

Abstract

Estrogens are known for their proliferative effects, resulting in tumorigenesis and causing cancers. The majority of breast cancers are estrogen-dependent. Estrogenb-locking drugs developed for treating estrogen-dependent breast cancers include antagonists of estrogen receptors (ERs) and inhibitors of estrogen synthesis enzymes such as aromatase and steroid sulfatase (STS). However, drugs targeting estrogen inactivation enzyme, estrogen sulfotransferase (SULT1E1), have not been developed for estrogen-dependent cancer treatment or prevention. Estrogens must be inactivated after their actions

Indexed as

Breast Cancer TreatmentEstrogen-Dependent Breast CancerEstrogen SulfotransferaseFlavonoidGene RegulationPreventionQuercetin

Identifiers

PMID36312461
PMCPMC9611654
OpenAlexW2996187326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.