Evidence map›Paper›PMID 36312441›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2020

DNAzyme-Mediated Genetically Encoded Sensors for Ratiometric Imaging of Metal Ions in Living Cells.

Mengyi Xiong, Zhenglin Yang, Ryan J Lake, Junjie Li, Shanni Hong, Huanhuan Fan, Xiao-Bing Zhang, Yi Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mengyi XiongMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 410082 (P. R. China).
Zhenglin YangDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Ryan J LakeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Junjie LiDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Shanni HongDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Huanhuan FanMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 410082 (P. R. China).
Xiao-Bing ZhangMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 410082 (P. R. China).
Yi LuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
University of Illinois Urbana-Champaign · USHunan University · CN

Funding

Selection and Sensing Applications of DNAzymes Selective for Paramagnetic Metal IonsR01GM124316 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LU, YI · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM124316
6 · The paper itself

Abstract

Genetically encoded fluorescent proteins (FPs) have been used for metal ion detection. However, their applications are restricted to a limited number of metal ions owing to the lack of available metal-binding proteins or peptides that can be fused to FPs and the difficulty in transforming the binding of metal ions into a change of fluorescent signal. We report herein the use of Mg

Indexed as

DNAzymeFluoreszierende ProteineGenetisch kodierte SensorenMetallionen

Identifiers

PMID36312441
PMCPMC9615436
OpenAlexW4256339129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.