Evidence map›Paper›PMID 36312416›Full record

ArticleACS omega2022

Isolation of a Peptide That Binds to

Soo Khim Chan, Zhongchao Zhao, Samuel Penziner, Ethan Khong, David Pride, Robert T Schooley, Nicole F Steinmetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soo Khim ChanDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.
Zhongchao ZhaoDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-3736-6677
Samuel PenzinerDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.
Ethan KhongDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.
David PrideDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.
Robert T SchooleyDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.
Nicole F SteinmetzDepartment of NanoEngineering, Department of Medicine, Department of Pathology, Department of Bioengineering, Department of Radiology, Center for Nano-ImmunoEngineering, Moores Cancer Center, and Institute for Materials Discovery and Design, University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-0130-0481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a global health threat that is exacerbated by the overuse and misuse of antibiotics in medicine and agriculture. As an alternative to conventional antimicrobial drugs, phage therapy involves the treatment of infected patients with a bacteriophage that naturally destroys bacterial pathogens. With the re-emergence of phage therapy, novel tools are needed to study phages. In this work we set out to screen and isolate peptide candidates that bind to phages and act as affinity tags. Such peptides functionalized with an imaging agent could serves as versatile tools for tracking and imaging of phages. Specifically, we screened a phage display library for peptides that bind to the Good Vibes phage (GV), which lyses the bacterial pathogen

Identifiers

PMID36312416
PMCPMC9609082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.