Evidence map›Paper›PMID 36312298›Full record

ArticleFrontiers in neuroanatomy2022

Neuroprotective effect of naringin against cerebellar changes in Alzheimer's disease through modulation of autophagy, oxidative stress and tau expression: An experimental study.

Hend M Hassan, Mohamed R Elnagar, Eman Abdelrazik, Mohamed R Mahdi, Eman Hamza, Eman M Elattar, Eman Mohamed ElNashar, Mansour Abdullah Alghamdi, Zainah Al-Qahtani, Khulood Mohammed Al-Khater and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroanatomy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Naringin Reverses Chronic Stress-Induced Cognitive Deficits and Enhances Hippocampal Neuroplasticity in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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  17. Neuroprotective Effects ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Hend M HassanDepartment of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mohamed R ElnagarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Eman AbdelrazikDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mohamed R MahdiDepartment of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Eman HamzaDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Eman M ElattarDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Eman Mohamed ElNasharDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Mansour Abdullah AlghamdiDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Zainah Al-QahtaniNeurology Section, Department of Internal Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Khulood Mohammed Al-KhaterDepartment of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Rashid A AldahhanDepartment of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Mamdouh ELdesoquiDepartment of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mansoura University · EGImam Abdulrahman Bin Faisal University · SAKing Khalid University · SAAl-Azhar University · EGBenha University · EGDamietta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce the likelihood of developing oxidative stress-related degenerative diseases such as AD. Naringin, a flavonoid found in citrus fruit shown to be neuroprotective, reduce oxidative damage and minimize histopathological changes caused by ischemic reperfusion, enhance the long-term memory in AD animal models. This work aimed to comprehend the role of naringin in the defense of the cerebellum against aluminum chloride (AlCl

Indexed as

aluminum chlorideAlzheimer’s diseaseautophagycerebellumnaringinoxidative stress

Identifiers

PMID36312298
PMCPMC9615142
OpenAlexW4306173283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.