ArticleFrontiers in neuroanatomy2022
Antigenicity is preserved with fixative solutions used in human gross anatomy: A mice brain immunohistochemistry study.
Article in Frontiers in neuroanatomy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Evaluation of lactic acid as a novel fixative for histological and neuroanatomical applications.Scientific reports · 2026Article
- Mechanical perfusion in brain banking: methods of assessment and relationship to the postmortem interval.Free neuropathology · 2025Article
- Comparison of histological procedures and antigenicity of human post-mortem brains fixed with solutions used in gross anatomy laboratories.Frontiers in neuroanatomy · 2024Article
- Article
- Ex situ perfusion fixation for brain banking: a technical report.Free neuropathology · 2022Article
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4 authors.
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Abstract
Background: Histology remains the gold-standard to assess human brain biology, so Materials and methods: Twenty-eight C57BL/6J mice were perfused with 4% formaldehyde (FAS, Results: The perfusion quality was better using FAS and worse using AS. The manipulation was very poor in SSS brains. FAS- and AS-fixed brains showed higher tissue and immunohistochemistry quality than the SSS brains. All antigens were readily observed in every specimen, regardless of the fixative solution. Conclusion: Solutions designed to preserve specimens for human gross anatomy dissections also preserve tissue antigenicity in different brain cells. This offers opportunities for the use of human brains fixed in gross anatomy laboratories to assess normal or pathological conditions.
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