ArticleFrontiers in neuroscience2022
Associations of circadian rest/activity rhythms with cognition in middle-aged and older adults: Demographic and genetic interactions.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2023Trial
- Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study.medRxiv : the preprint server for health sciences · 2026Article
- Alzheimer's disease polygenic risk, APOE ε4 dose, and accelerometer-derived circadian rest-activity rhythms in relation to incident dementia and Alzheimer's disease in UK Biobank: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- The influence of physical activity on circadian syndrome: a nationwide prospective study based on the CHARLS cohort.BMC public health · 2026Article
- Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Association of physical activity and rest-activity rhythm with sustained attention and melatonin among community-dwelling older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Dose-Response Relationship Between Sleep Regularity Index and Stage-Specific Alzheimer's Disease: Cross-Sectional Evidence from Japanese Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Control vs. salience: a new axis of circadian brain-body organization.Npj biological timing and sleep · 2026Article
- Circadian syndrome, not metabolic syndrome, is a significant predictor of mild cognitive impairment in middle-aged and older adults - The CHARLS survey during 2015-2018.BMC public health · 2026Article
- Move to Remember: The Role of Physical Activity and Exercise in Preserving and Enhancing Cognitive Function in Aging-A Narrative Review.Geriatrics (Basel, Switzerland) · 2025Review
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- White matter microstructure statistically mediates associations between circadian rest/activity rhythms and cognition in older adults.Sleep advances : a journal of the Sleep Research Society · 2025Article
- From Steps to Context: Optimizing Digital Phenotyping for Physical Activity Monitoring in Older Adults by Integrating Wearable Data and Ecological Momentary Assessment.Sensors (Basel, Switzerland) · 2025Article
- Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology.Alzheimer's research & therapy · 2024Article
- Cognition and Activity of Daily Living Function in people with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Associations between circadian alignment and cognitive functioning in a nationally representative sample of older adults.Scientific reports · 2024Article
- Characteristics of 24-hour movement behaviours and their associations with mental health in children and adolescents.Journal of activity, sedentary and sleep behaviors · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Objectives: Wrist actigraphs (accelerometers) can record motor activity over multiple days and nights. The resulting data can be used to quantify 24-h activity profiles, known as circadian rest-activity rhythms (CRARs). Actigraphic CRARs have been tied to cognitive performance and decline in older adults; however, little is known about links between CRARs and performance or change in specific cognitive domains, or how individual differences may influence these associations. We investigated associations of actigraphic CRARs with cognitive performance and change in middle-aged and older adults, and explored whether age, sex/gender, race, and apolipoprotein E (APOE) e4 carrier status moderated these associations. Materials and methods: Participants ( Results: In main effects, later L5 time was cross sectionally associated with poorer memory, and greater IS predicted slower longitudinal memory decline. Associations of CRARs with cognition differed as a function of age, sex/gender, race, and APOE e4 carrier status. Conclusion: Among middle-aged and older adults, delayed circadian phase is associated with poorer memory performance, and greater day-to-day rhythm stability is associated with slower declines in memory. Significant interactions suggest that CRARs are generally more strongly associated with cognitive performance and rate of cognitive decline among women, Black adults, older individuals, and APOE e4 carriers. Replication in independent samples is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.