Evidence map›Paper›PMID 36311870›Full record

ArticleEuropean journal of plastic surgery2023

The effect of tranexamic acid on blood loss in liposuction: a randomized controlled study.

Hisham M El Minawi, Hamed M Kadry, Nadeen M El-Essawy, Zainab A El Saadany, Omar M Nouh

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of plastic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06419075 (Local Infiltration of TranExamic Acid in Surgical Management of Pelvic Organ Prolapse), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06419075 phase4withdrawnnot on this mapstarted 2024, after this paper: background citation

Local Infiltration of TranExamic Acid in Surgical Management of Pelvic Organ Prolapse: a Pilot Randomized Clinical Trial

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2024 to 2025Enrolled0ConditionsPelvic Organ ProlapseArmsTranexamic acid, Vasopressin, NaCl 0.9%
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hisham M El MinawiPlastic and Reconstructive Surgery, Faculty of Medicine, Cairo University, 1 salah Aldin Street, from Ring Road, Alhadaba Alwosta, Mokattam, Cairo, Egypt.
Hamed M KadryPlastic and Reconstructive Surgery, Faculty of Medicine, Cairo University, 1 salah Aldin Street, from Ring Road, Alhadaba Alwosta, Mokattam, Cairo, Egypt.
Nadeen M El-EssawyPlastic and Reconstructive Surgery, Cairo University, Cairo, Egypt.
Zainab A El SaadanyClinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Omar M NouhPlastic and Reconstructive Surgery, Faculty of Medicine, Cairo University, 1 salah Aldin Street, from Ring Road, Alhadaba Alwosta, Mokattam, Cairo, Egypt.ORCID 0000-0001-7599-6912

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Liposuction is one of the most common procedures in the practice of plastic surgery. Since it evolved, continuous modifications have been to decrease blood loss so that patients are hemodynamically stable intra- and postoperatively. Tranexamic acid (TXA) has long been used for its antifibrinolytic properties that were beneficial in reducing blood loss, rate of transfusion, and hemoglobin drop in major trauma and surgeries. Its use in plastic surgery, however, is still limited. In this study, we aim to illustrate the effect of intravenous (IV) and local infiltration of TXA on blood loss in liposuction surgery. Methods: Between April 2019 and April 2021, 90 patients who requested liposuction for various body parts were randomly allocated into 3 equal groups: control group, IV TXA, and local infiltration of TXA. A sample was taken from infranatant and sent for hematocrit calculation. Volume of blood in lipoaspirate was then calculated. Patients were assessed for blood loss and postoperative bruising. Results: Volume of blood loss in lipoaspirate was considerably lower in the TXA groups, with 60% decrease in blood loss for the local TXA group in comparison with the control group. TXA has also been shown to markedly decrease bruising tendency in postoperative liposuction patients. Conclusions: TXA can be used to decrease blood loss in large-volume liposuction, modify the need for blood transfusion intra- and postoperative, and improve the results of liposuction procedure without the need for multiple sessions. Level of evidence: Level II, Risk/Prognostic Study.

Indexed as

AntifibrinolyticsHigh-volume liposuctionLiposculptureLiposuctionTranexamic acid

Identifiers

PMID36311870
PMCPMC9589853

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.