ArticleJACS Au2022
Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First
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Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed.
- A nickel N-heterocyclic biscarbene complex derived from caffeine enhances fluconazole efficacy againstMicrobiology spectrum · 2026Article
- Metal-Based Photosensitizers as Emerging Antibacterial Agents for Infected Wound Healing.ChemMedChem · 2026Review
- Evaluation of the antifungal potential of N, N chelating iridium(III) complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- In Vivo Evaluation of a Nanoemulsion-Delivered Chromium(III)-Triazole Complex Against Fluconazole-ResistantJournal of fungi (Basel, Switzerland) · 2026Article
- A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy.npj antimicrobials and resistance · 2026Article
- Evaluating the Antiproliferative Effects of Tri(2-Furyl)- and Triphenylphosphine-Gold(I) Pyridyl- and Pyrimidine-Thiolate Complexes.Biomolecules · 2026Article
- Metal-based triazoles as a medical marvel of the modern era: a comprehensive review.RSC advances · 2026Review
- Cyclopalladated Complexes With Functionalized Diphosphanes as Promising Antifungal Scaffolds.Bioinorganic chemistry and applications · 2026Article
- Investigation of a Homoleptic Nickel(II) Complex: Synthesis, Crystal Structure, Computational Insights, and Antimicrobial Efficacy.ACS omega · 2025Article
- Amphiphile-Assisted Synthesis of Ruthenium Nanoparticles for Controlled Release and Enhanced Antibacterial Activity.Small methods · 2025Article
- Biological Activity of Silver(I)-1,10-Phenanthroline Complexes AgainstPharmaceuticals (Basel, Switzerland) · 2025Article
- Machine Learning-Guided Design of Rhenium Tricarbonyl Complexes for Next-Generation Antibiotics.ACS bio & med chem Au · 2025Article
- Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin.International journal of molecular sciences · 2025Review
- Uncovering the antifungal potential of Cannabidiol and Cannabidivarin.PLoS neglected tropical diseases · 2025Article
- Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IPACS infectious diseases · 2025Article
- Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.Journal of medicinal chemistry · 2025Review
- Linking Research Data with Physically Preserved Research Materials in Chemistry.Scientific data · 2025Article
- Unveiling the antifungal mechanisms of CTP, a new copper(II)-theophylline/1,10-phenanthroline complex, on drug-resistant non-albicans Candida species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.Nature communications · 2024Article
- Spectrum of activity and mechanisms of azole-bisphosphonate synergy in pathogenicMicrobiology spectrum · 2024Article
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Authors and funding
28 authors.
Angelo FreiCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia.
Alysha G ElliottCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia.ORCID https://orcid.org/0000-0002-2983-0484
Alex KanMolecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, Sydney Institute for Infectious Diseases, Westmead Hospital-Research and Education Network, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW2145, Australia.
Hue DinhSchool of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW2109, Australia.
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131Karlsruhe, Germany.
Alice E BruceDepartment of Chemistry, University of Maine, Orono, Maine04469, United States.ORCID https://orcid.org/0000-0002-4556-8180
Mitchell R BruceDepartment of Chemistry, University of Maine, Orono, Maine04469, United States.ORCID https://orcid.org/0000-0002-6428-3842
Feng ChenDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, U.K.
Dhirgam HumaidyDepartment of Chemistry, University of Maine, Orono, Maine04469, United States.
Nicole JungKarlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344Eggenstein-Leopoldshafen, Germany.ORCID https://orcid.org/0000-0001-9513-2468
A Paden KingDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York14853, United States.
Peter G LyeSchool of Science and Technology, University of New England, Armidale, NSW2351, Australia.
Hanna K MaliszewskaSchool of Chemistry, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, U.K.
Ahmed M MansourChemistry Department, Faculty of Science, Cairo University, Giza12613, Egypt.ORCID https://orcid.org/0000-0002-0877-3636
Dimitris MatiadisInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310Athens, Greece.ORCID https://orcid.org/0000-0003-0059-952X
María Paz MuñozSchool of Chemistry, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, U.K.
Tsung-Yu PaiMolecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, Sydney Institute for Infectious Diseases, Westmead Hospital-Research and Education Network, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW2145, Australia.
Shyam PokhrelDepartment of Chemistry, University of Maine, Orono, Maine04469, United States.
Peter J SadlerDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, U.K.ORCID https://orcid.org/0000-0001-9160-1941
Marina SagnouInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310Athens, Greece.ORCID https://orcid.org/0000-0002-4231-6658
Michelle TaylorSchool of Science and Technology, University of New England, Armidale, NSW2351, Australia.
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York14853, United States.ORCID https://orcid.org/0000-0002-4086-7982
Dean WoodsSchool of Science and Technology, University of New England, Armidale, NSW2351, Australia.
Johannes ZueggCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia.ORCID https://orcid.org/0000-0001-6240-6020
Wieland MeyerMolecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, Sydney Institute for Infectious Diseases, Westmead Hospital-Research and Education Network, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW2145, Australia.
Amy K CainSchool of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW2109, Australia.
Matthew A CooperCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia.ORCID https://orcid.org/0000-0003-3147-3460
Mark A T BlaskovichCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia.ORCID https://orcid.org/0000-0001-9447-2292
Funding
CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4MNIGMS NIH HHS T32 GM008500Wellcome Trust
Abstract
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal strains that are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be promising candidates for novel antibiotics, but so far, few compounds have been explored for their potential application as antifungal agents. In this work, we report the evaluation of 1039 metal-containing compounds that were screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD). We show that 20.9% of all metal compounds tested have antimicrobial activity against two representative
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