Evidence map›Paper›PMID 36311799›Full record

ArticleFrontiers in immunology2022

Human MHC class I molecule, HLA-A2.1, mediates activation of CD8

Rajesh Mani, Mohamed H Abdelaziz, Alexandra Michelon, Yasuhiro Suzuki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rajesh ManiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
Mohamed H AbdelazizDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
Alexandra MichelonDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
University of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cystsR01AI095032 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2012 to 2023
$4.1M
Key sentinel roles of IFN-gamma production by microglia to orchestrate the innate and T cell-mediated protective immunity to prevent reactivation of cerebral Toxoplasma infectionR56AI152597 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2020 to 2020
$493k
Gender-dependent innate IL-10 production as a key pathogenic factor to promote toxoplasmic encephalitisR21AI136821 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2018 to 2019
$421k
NCI NIH HHS P30 CA177558NIAID NIH HHS R01 AI095032NIAID NIH HHS R21 AI136821NIAID NIH HHS R56 AI152597
6 · The paper itself

Abstract

To examine whether the HLA-A2.1, one of the most common MHC class I molecules in humans, activates the protective immunity against reactivation of cerebral infection with

Indexed as

ToxoplasmaAnimalsCD8-Positive T-LymphocytesHLA-A2 AntigenHumansInterferon-gammaMiceMice, Inbred BALB CMice, TransgenicSulfadiazineHLA-A2 AntigenInterferon-gammaSulfadiazineCD8+ T cellcerebral infectionchronic infectionHLA-A2.1humanize mice modelToxoplasma gondiitoxoplasmic encephalitis

Identifiers

PMID36311799
PMCPMC9606666
OpenAlexW4304845591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.