Evidence map›Paper›PMID 36311768›Full record

ArticleFrontiers in immunology2022

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise.

Ana P Pinto, Vitor R Muñoz, Alisson L da Rocha, Rafael L Rovina, Gustavo D Ferrari, Luciane C Alberici, Fernando M Simabuco, Giovana R Teixeira, José R Pauli, Leandro P de Moura and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  6. Exerkines and myokines in aging sarcopenia.Frontiers in endocrinology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ana P PintoSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Vitor R MuñozSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Alisson L da RochaPostgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil.
Rafael L RovinaSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Gustavo D FerrariDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo (FCFRP USP), Sao Paulo, Brazil.
Luciane C AlbericiDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo (FCFRP USP), Sao Paulo, Brazil.
Fernando M SimabucoLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Giovana R TeixeiraMulticentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), São Paulo, Brazil.
José R PauliLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Leandro P de MouraLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Dennys E CintraLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Eduardo R RopelleLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Ellen C FreitasSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Donato A RivasMulticentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), São Paulo, Brazil.
Adelino S R da SilvaSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade de Ribeirão Preto · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin 6 (IL-6) acts as a pro and anti-inflammatory cytokine, has an intense correlation with exercise intensity, and activates various pathways such as autophagy and mitochondrial unfolded protein response. Also, IL-6 is interconnected to circadian clock-related inflammation and can be suppressed by the nuclear receptor subfamily 1, group D, member 1 (

Indexed as

Interleukin-6Nuclear Receptor Subfamily 1, Group D, Member 1AnimalsAutophagyBiomarkersGene Products, revMiceMuscle, SkeletalPyrrolidinesThiophenesBiomarkersGene Products, revInterleukin-6interleukin-6, mouseNr1d1 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1PyrrolidinesSR9009Thiophenesautophagic fluxC2C12 cellsgenetic deletionmitochondriaNr1d1pharmacological treatment

Identifiers

PMID36311768
PMCPMC9608639
OpenAlexW4304892066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.