Evidence map›Paper›PMID 36311725›Full record

ArticleFrontiers in immunology2022

Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft-versus-host-disease.

Thomas Krüger, Rebekka Wehner, Maik Herbig, Martin Kräter, Michael Kramer, Jan Moritz Middeke, Friedrich Stölzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Thomas KrügerDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Rebekka WehnerGerman Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Maik HerbigMax Planck Institute for Science of Light and Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.
Martin KräterMax Planck Institute for Science of Light and Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.
Michael KramerDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Jan Moritz MiddekeDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Friedrich StölzelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Catrin ListDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Katharina Egger-HeidrichDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Raphael TeipelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Uta OelschlägelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Martin WermkeDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Helena JamborDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Manja WobusDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Johannes ScheteligDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Korinna JöhrensInstitute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany.
Torsten TonnInstitute of Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Julien SubburayaluDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Marc SchmitzGerman Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Martin BornhauserDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Malte von BoninDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
University Hospital Carl Gustav Carus · DETU Dresden · DEHeidelberg University · DEBerlin-Brandenburger Centrum für Regenerative Therapien · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional impairment of the bone marrow (BM) niche has been suggested as a major reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic cell transplantation (alloHCT). Because mesenchymal stromal cells (MSCs) serve as multipotent progenitors for several niche components in the BM, they might play a key role in this process. We used collagenase digested trephine biopsies to directly quantify MSCs in 73 patients before (n = 18) and/or after alloHCT (n = 65). For the first time, we demonstrate that acute graft-versus-host disease (aGvHD, n = 39) is associated with a significant decrease in MSC numbers. MSC reduction can be observed even before the clinical onset of aGvHD (n = 10). Assessing MSCs instantly after biopsy collection revealed phenotypic and functional differences depending on the occurrence of aGvHD. These differences vanished during

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationMesenchymal Stem CellsMesenchymal Stem Cell TransplantationBone MarrowHumansallogeneic hematopoietic stem cell transplantationalloreactivitybone marrow nichegraft-versus-host-diseasemesenchymal stromal cells

Identifiers

PMID36311725
PMCPMC9599394
OpenAlexW4304693472

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.