Evidence map›Paper›PMID 36311537›Full record

ReviewFaculty reviews2022

Recent updates in the treatment of diabetic polyneuropathy.

Qihua Fan, A Gordon Smith

Abstract readReview
In one paragraph

Review in Faculty reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. The Role of Novel Biomarkers in the Early Management of Peripheral Diabetic Neuropathy.Central nervous system agents in medicinal chemistry · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qihua FanDepartment of Neurology, Division of Neuromuscular Medicine, Virginia Commonwealth University, Richmond, VA, USA.
A Gordon SmithDepartment of Neurology, Division of Neuromuscular Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Funding

The Utah Diabetic Neuropathy StudyR01DK064814 · NIDDK · UNIVERSITY OF UTAH · PI SINGLETON, JOHN ROBINSON, SMITH, A. GORDON · 2004 to 2019
$7.8M
Topiramate as a Disease Altering Therapy for CSPNU01NS095388 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI COFFEY, CHRISTOPHER S., CUDKOWICZ, MERIT E · 2017 to 2020
$7.3M
Remote Monitoring of Management of Chemotherapy induced Peripheral NeuropathyR01CA247517 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Noah Allan Kolb, KATHLEEN H MOONEY · 2021 to 2026
$6.5M
NCI NIH HHS R01 CA247517NIDDK NIH HHS R01 DK064814NINDS NIH HHS U01 NS095388
6 · The paper itself

Abstract

Distal symmetric diabetic peripheral polyneuropathy (DPN) is the most common form of neuropathy in the world, affecting 30 to 50% of diabetic individuals and resulting in significant morbidity and socioeconomic costs. This review summarizes updates in the diagnosis and management of DPN. Recently updated clinical criteria facilitate bedside diagnosis, and a number of new technologies are being explored for diagnostic confirmation in specific settings and for use as surrogate measures in clinical trials. Evolving literature indicates that distinct but overlapping mechanisms underlie neuropathy in type 1 versus type 2 diabetes, and there is a growing focus on the role of metabolic factors in the development and progression of DPN. Exercise-based lifestyle interventions have shown therapeutic promise. A variety of potential disease-modifying and symptomatic therapies are in development. Innovations in clinical trial design include the incorporation of detailed pain phenotyping and biomarkers for central sensitization.

Indexed as

biomarkersdiabetic polyneuropathygenetic modifiersmetabolic syndromeneuropathic painobesitytherapeutics

Identifiers

PMID36311537
PMCPMC9586156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.