Evidence map›Paper›PMID 36311166›Full record

ArticleCancer research communications2022

The Tumor Immune Profile of Murine Ovarian Cancer Models: An Essential Tool For Ovarian Cancer Immunotherapy Research.

Galaxia M Rodriguez, Kristianne J C Galpin, David P Cook, Edward Yakubovich, Vincent Maranda, Elizabeth A Macdonald, Juliette Wilson-Sanchez, Anjali L Thomas, Joanna E Burdette, Barbara C Vanderhyden

Abstract read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  4. NKG2A inhibition promotes NK cell-CD8Nature communications · 2026
    Article
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  12. Loss ofOncotarget · 2025
    Article
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  15. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Galaxia M RodriguezCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Kristianne J C GalpinCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
David P CookCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Edward YakubovichCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Vincent MarandaCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Elizabeth A MacdonaldCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Juliette Wilson-SanchezCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Anjali L ThomasCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607.
Barbara C VanderhydenCancer Therapeutic Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario Canada, K1H 8L6.

Funding

Microfluidic Models of Ovarian Cancer Preneoplastic LesionsR01CA240301 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, Jonathan Coppeta · 2019 to 2026
$4.6M
Imaging mass spectrometry methodologies for studying the metabolites of cancer metastasisR01CA240423 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E, SANCHEZ, LAURA MARGARET · 2020 to 2024
$2.1M
NCI NIH HHS R01 CA240301NCI NIH HHS R01 CA240423
6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer with an imperative need for new treatments. Immunotherapy has had marked success in some cancer types; however, clinical trials studying the efficacy of immune checkpoint inhibitors for the treatment of EOC benefited less than 15% of patients. Given that EOC develops from multiple tissues in the reproductive system and metastasizes widely throughout the peritoneal cavity, responses to immunotherapy are likely hindered by heterogeneous tumor microenvironments (TME) containing a variety of immune profiles. To fully characterize and compare syngeneic model systems that may reflect this diversity, we determined the immunogenicity of six ovarian tumor models

Indexed as

Ovarian NeoplasmsProto-Oncogene Proteins p21(ras)AnimalsCarcinoma, Ovarian EpithelialFemaleHumansImmunotherapyMiceTumor MicroenvironmentProto-Oncogene Proteins p21(ras)cold versus hot tumorsimmunogenicityovarian cancertumor infiltrating immune cellstumor mutational burden

Identifiers

PMID36311166
PMCPMC9616009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.