Evidence map›Paper›PMID 36311026›Full record

ReviewFrontiers in molecular neuroscience2022

Zebrafish as a model organism for neurodegenerative disease.

Kelda Chia, Anna Klingseisen, Dirk Sieger, Josef Priller

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Modeling versatility as the hallmark of model organisms.History and philosophy of the life sciences · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Unraveling the impact ofBrain communications · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Zebrafish: A Versatile and Powerful Model for Biomedical Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kelda ChiaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Anna KlingseisenCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Dirk SiegerCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Josef PrillerCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zebrafish is increasingly recognized as a model organism for translational research into human neuropathology. The zebrafish brain exhibits fundamental resemblance with human neuroanatomical and neurochemical pathways, and hallmarks of human brain pathology such as protein aggregation, neuronal degeneration and activation of glial cells, for example, can be modeled and recapitulated in the fish central nervous system. Genetic manipulation, imaging, and drug screening are areas where zebrafish excel with the ease of introducing mutations and transgenes, the expression of fluorescent markers that can be detected

Indexed as

Alzheimer’s diseaseamyotrophic lateral sclerosis (ALS)Huntington’s disease (HD)multiple sclerosisParkinson’s diseasezebrafish

Identifiers

PMID36311026
PMCPMC9606821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.