Evidence map›Paper›PMID 36310512›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Higher Levels of Cerebrospinal Fluid and Plasma Neurofilament Light in Human Immunodeficiency Virus-Associated Distal Sensory Polyneuropathy.

Ronald J Ellis, Ahmed Chenna, Yolanda Lie, Dusica Curanovic, John Winslow, Bin Tang, Christina M Marra, Leah H Rubin, David B Clifford, J Allen McCutchan and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Ronald J EllisDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.ORCID 0000-0003-4931-752X
Ahmed ChennaMonogram Biosciences, South San Francisco, California, USA.
Yolanda LieMonogram Biosciences, South San Francisco, California, USA.
Dusica CuranovicMonogram Biosciences, South San Francisco, California, USA.
John WinslowMonogram Biosciences, South San Francisco, California, USA.
Bin TangDepartment of Psychiatry, University of California, San Diego, San Diego, California, USA.
Christina M MarraDeparment of Neurology, University of Washington, Seattle, Washington, USA.
Leah H RubinDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
David B CliffordDepartment of Neurology, Washington University at St. Louis, St. Louis, Missouri, USA.
J Allen McCutchanDepartment of Medicine, University of California San Diego, San Diego, California, USA.
Benjamin B GelmanDepartment of Neuroscience and Cell Biology, UTMB, Galveston, Texas, USA.
Jessica Robinson-PappDepartment of Neurology, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
Christos J PetropoulosMonogram Biosciences, South San Francisco, California, USA.
Scott L LetendreDepartments of Medicine and Psychiatry, University of California, San Diego, San Diego, California, USA.
University of California San Diego · USGalveston College · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USUniversity of Washington · USWashington University in St. Louis · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345
6 · The paper itself

Abstract

backgroundNeurofilament light (NFL) chain concentrations, reflecting axonal damage, are seen in several polyneuropathies but have not been studied in human immunodeficiency virus (HIV) distal sensory polyneuropathy (DSP). We evaluated NFL in cerebrospinal fluid (CSF) and plasma in relation to DSP in people with HIV (PWH) from 2 independent cohorts and in people without HIV (PWoH).

methodsCohort 1 consisted of PWH from the CHARTER Study. Cohort 2 consisted of PWH and PWoH from the HIV Neurobehavioral Research Center (HNRC). We evaluated DSP signs and symptoms in both cohorts. Immunoassays measured NFL in CSF for all and for plasma as well in Cohort 2.

resultsCohort 1 consisted of 111 PWH, mean ± SD age 56.8 ± 8.32 years, 15.3% female, 38.7% Black, 49.6% White, current CD4+ T-cells (median, interquartile range [IQR]) 532/µL (295, 785), 83.5% with plasma HIV RNA ≤50 copies/mL. Cohort 2 consisted of 233 PWH of similar demographics to PWH in Cohort 1 but also 51 PWoH, together age 58.4 ± 6.68 years, 41.2% female, 18.0% Black, Hispanic, non-Hispanic White 52.0%, 6.00% White. In both cohorts of PWH, CSF and plasma NFL were significantly higher in both PWH with DSP signs. Findings were similar, albeit not significant, for PWoH. The observed relationships were not explained by confounds.

conclusionsBoth plasma and CSF NFL were elevated in PWH and PWoH with DSP. The convergence of our findings with others demonstrates that NFL is a reliable biomarker reflecting peripheral nerve injury. Biomarkers such as NFL might provide, validate, and optimize clinical trials of neuroregenerative strategies in HIV DSP.

Indexed as

HIV InfectionsPolyneuropathiesAgedBiomarkersFemaleHIVHumansIntermediate FilamentsMaleMiddle AgedBiomarkersbiomarkercerebrospinal fluidHIVneurofilament lightpolyneuropathy

Identifiers

PMID36310512
PMCPMC10226757
OpenAlexW4307771474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.