Evidence map›Paper›PMID 36310444›Full record

ReviewAntioxidants & redox signaling2023

Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting.

Joshua R Huot, Dryden Baumfalk, Aridai Resendiz, Andrea Bonetto, Ashley J Smuder, Fabio Penna

Open access · greenAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 23 citations in OpenAlex.

  1. Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategies.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
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  17. Deuterated Polyunsaturated Fatty Acids AlleviatebioRxiv : the preprint server for biology · 2025
    Article
  18. Anti-Colorectal Cancer Activity ofInternational journal of molecular sciences · 2025
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Joshua R HuotDepartment of Surgery and Indiana University School of Medicine, Indianapolis, Indiana, USA.
Dryden BaumfalkDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Aridai ResendizDepartment of Oncology, Surgical Oncology and Digestive Surgery Unit, S Luigi University Hospital, University of Torino, Torino, Italy.
Andrea BonettoDepartment of Surgery and Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ashley J SmuderDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Fabio PennaDepartment of Clinical and Biological Sciences, University of Torino, Torino, Italy.ORCID 0000-0002-2774-6027
University of Florida · USUniversity of Turin · ITIndiana University Health · USIndiana University – Purdue University Indianapolis · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Targeting RANKL for the treatment of muscle and bone defects in cachexiaR01AR079379 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Andrea Bonetto · 2021 to 2026
$2.1M
Doxorubicin-induced respiratory dysfunction and the protective effects of exerciseR01HL146443 · NHLBI · UNIVERSITY OF FLORIDA · PI SMUDER, ASHLEY · 2019 to 2023
$1.9M
FGF21-IGFBP1 axis mediates musculoskeletal deficits in colorectal cancer cachexiaF32AR079256 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI HUOT, JOSHUA · 2022 to 2022
$23k
NHLBI NIH HHS R01 HL146443NIAMS NIH HHS F32 AR079256NIAMS NIH HHS R01 AR079379NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsNeoplasmsCachexiaHumansMitochondriaMuscle, SkeletalMuscular AtrophyOxidative StressAntineoplastic Agentsantioxidantscancerchemotherapynutraceuticalswasting

Identifiers

PMID36310444
PMCPMC10081727
OpenAlexW4307771793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.