ArticleCommunications biology2022
Cortical gradient of a human functional similarity network captured by the geometry of cytoarchitectonic organization.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Human cerebral cortex organization characterized by functional PET-FDG "Metabolic Connectivity".European journal of nuclear medicine and molecular imaging · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Human Cerebral Cortex Organization Characterized by Functional PET-FDG "Metabolic Connectivity".bioRxiv : the preprint server for biology · 2026Article
- Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder.Psychological medicine · 2025Article
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
- A Method for Estimating Dynamic Functional Network Connectivity Gradients (dFNGs) From ICA Captures Smooth Inter-Network Modulation.Human brain mapping · 2025Article
- Cortical morphometric similarity gradient in schizophrenia and its association with transcriptional profiles and clinical phenotype.Psychological medicine · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- A method for estimating dynamic functional network connectivity gradients (dFNG) from ICA captures smooth inter-network modulation.bioRxiv : the preprint server for biology · 2024Article
- Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance.PLoS biology · 2024Article
- Functional gradients reveal cortical hierarchy changes in multiple sclerosis.Human brain mapping · 2024Article
- Rhythmicity of neuronal oscillations delineates their cortical and spectral architecture.Communications biology · 2024Article
- Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets.Nature communications · 2024Article
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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7 authors.
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Abstract
Mapping the functional topology from a multifaceted perspective and relating it to underlying cross-scale structural principles is crucial for understanding the structural-functional relationships of the cerebral cortex. Previous works have described a sensory-association gradient axis in terms of coupling relationships between structure and function, but largely based on single specific feature, and the mesoscopic underpinnings are rarely determined. Here we show a gradient pattern encoded in a functional similarity network based on data from Human Connectome Project and further link it to cytoarchitectonic organizing principles. The spatial distribution of the primary gradient follows an inferior-anterior to superior-posterior axis. The primary gradient demonstrates converging relationships with layer-specific microscopic gene expression and mesoscopic cortical layer thickness, and is captured by the geometric representation of a myelo- and cyto-architecture based laminar differentiation theorem, involving a dual origin theory. Together, these findings provide a gradient, which describes the functional topology, and more importantly, linking the macroscale functional landscape with mesoscale laminar differentiation principles.
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