Evidence map›Paper›PMID 36310033›Full record

ReviewDrug metabolism and disposition: the biological fate of chemicals2023

Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond.

Arthur G Roberts, Jeffrey C Stevens, Grazyna D Szklarz, Emily E Scott, Santosh Kumar, Manish B Shah, James R Halpert

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drug metabolism and disposition: the biological fate of chemicals, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Natural Products Inhibition of Cytochrome P450 2B6 Activity and Methadone Metabolism.Drug metabolism and disposition: the biological fate of chemicals · 2024
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arthur G RobertsPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.). audie@uga.edu.ORCID 0000-0001-6045-458X
Jeffrey C StevensPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
Grazyna D SzklarzPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
Emily E ScottPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
Santosh KumarPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
Manish B ShahPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
James R HalpertPharmaceutical and Biomedical Sciences Department, University of Georgia, 240 W. Green St., Athens, Georgia (A.G.R.); Unaffiliated (J.C.S.); Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (G.D.S.); Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry and the Program in Biophysics, University of Michigan, Ann Arbor, Michigan (E.E.S.); Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee (S.K.); Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York (M.B.S.); Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona (J.R.H.).
West Virginia University · US

Funding

Structural Basis of Cytochrome P450 Activity-Equipment SupplementR37GM076343 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT, EMILY E · 2015 to 2024
$3.7M
Overcoming Cancer Resistance Mediated by the Human MDR1 TransporterR01CA204846 · NCI · UNIVERSITY OF GEORGIA · PI ROBERTS, ARTHUR G · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA204846NIGMS NIH HHS R37 GM076343
6 · The paper itself

Abstract

This article features selected findings from the senior author and colleagues dating back to 1978 and covering approximately three-fourths of the 60 years since the discovery of cytochrome P450. Considering the vast number of P450 enzymes in this amazing superfamily and their importance for so many fields of science and medicine, including drug design and development, drug therapy, environmental health, and biotechnology, a comprehensive review of even a single topic is daunting. To make a meaningful contribution to the 50th anniversary of

Indexed as

Cytochrome P-450 Enzyme SystemDrug DesignAnimalsHumansMammalsRabbitsCytochrome P-450 Enzyme System

Identifiers

PMID36310033
PMCPMC11022898
OpenAlexW4307650852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.