Evidence map›Paper›PMID 36310009›Full record

ArticleCardiorenal medicine2022

APOL1 G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry.

Tae-Hwi Schwantes-An, Cassianne Robinson-Cohen, Sai Liu, Neil Zheng, Margaret Stedman, Leah Wetherill, Howard J Edenberg, Matteo Vatta, Tatiana M Foroud, Glenn M Chertow and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiorenal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tae-Hwi Schwantes-AnDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Memphis, Tennessee, USA.
Sai LiuDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Neil ZhengDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Memphis, Tennessee, USA.
Margaret StedmanDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Matteo VattaDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Glenn M ChertowDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Sharon M MoeDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University School of MedicineStanford University · USVanderbilt University · US

Funding

Investigating causality between abnormalities of mineral metabolism and kidney, cardiovascular and bone diseaseR01DK122075 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROBINSON-COHEN, CASSIANNE · 2019 to 2023
$1.9M
Genetic risks for cardiovascular events in ESRD patients from the EVOLVE study.R01DK100306 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M · 2014 to 2016
$1.0M
NIDDK NIH HHS R01 DK100306NIDDK NIH HHS R01 DK122075
6 · The paper itself

Abstract

introductionThe G1 and G2 variants in the APOL1 gene convey high risk for the progression of chronic kidney disease in African Americans. The G3 variant in APOL1 is more common in patients of European ancestry (EA); outcomes associated with this variant have not been explored previously in EA patients receiving dialysis.

methodsDNA was collected from approximately half of the patients enrolled in the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial and genotyped for the G3 variants. We utilized an additive genetic model to test associations of G3 with the EVOLVE adjudicated endpoints of all-cause mortality, cardiovascular mortality, sudden cardiac death (SCD), and heart failure. EA and African ancestry samples were analyzed separately. Validation was done in the Vanderbilt BioVU using ICD codes for cardiovascular events that parallel the adjudicated endpoints in EVOLVE.

resultsIn EVOLVE, G3 in EA patients was associated with the adjudicated endpoints of cardiovascular mortality and SCD. In a validation cohort from the Vanderbilt BioVU, cardiovascular events and cardiovascular mortality defined by ICD codes showed similar associations in EA participants who had been on dialysis for 2 to <5 years. DISCUSSION/

conclusionsG3 in APOL1 variant was associated with cardiovascular events and cardiovascular mortality in the EA patients receiving dialysis. This suggests that variations in the APOL1 gene that differ in populations of different ancestry may contribute to cardiovascular disease.

Indexed as

Apolipoprotein L1Heart FailureCinacalcetDeath, Sudden, CardiacHumansRenal DialysisAPOL1 protein, humanApolipoprotein L1CinacalcetCardiovascular diseaseDialysisGeneticsSudden cardiac death

Identifiers

PMID36310009
PMCPMC10445292
OpenAlexW4307712193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.