Evidence map›Paper›PMID 36309944›Full record

ArticlePest management science2023

Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations.

Inge M Krijger, Max Strating, Marga van Gent-Pelzer, Theo A J van der Lee, Sara A Burt, Fleur H Schroeten, Robin de Vries, Marieke de Cock, Miriam Maas, Bastiaan G Meerburg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
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Article in Pest management science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Inge M KrijgerDutch Pest and Wildlife Expertise Centre (KAD), Wageningen, the Netherlands.
Max StratingDutch Pest and Wildlife Expertise Centre (KAD), Wageningen, the Netherlands.
Marga van Gent-PelzerBusiness Unit Biointeractions, Wageningen University, Wageningen, the Netherlands.
Theo A J van der LeeBusiness Unit Biointeractions, Wageningen University, Wageningen, the Netherlands.
Sara A BurtInstitute for Risk Assessment Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, the Netherlands.
Fleur H SchroetenInstitute for Risk Assessment Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, the Netherlands.
Robin de VriesDutch Pest and Wildlife Expertise Centre (KAD), Wageningen, the Netherlands.
Marieke de CockCentre for Infectious Disease Control, National institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Miriam MaasCentre for Infectious Disease Control, National institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Bastiaan G MeerburgDutch Pest and Wildlife Expertise Centre (KAD), Wageningen, the Netherlands.
Dutch Expert Centre for Screening · NLNational Institute for Public Health and the Environment · NLUtrecht University · NLWageningen University & Research · NL

Funding

Dutch Ministry of Infrastructure and Environment
6 · The paper itself

Abstract

backgroundResistance to rodenticides has been reported globally and poses a considerable problem for efficacy in pest control. The most-documented resistance to rodenticides in commensal rodents is associated with mutations in the Vkorc1 gene, in particular in codon 139. Resistance to anticoagulant rodenticides has been reported in the Netherlands since 1989. A study from 2013 showed that 25% of 169 Norway rats (Rattus norvegicus) had a mutation at codon 139 of the Vkorc1 gene. To gain insight in the current status of rodenticide resistance amongst R. norvegicus and house mice Mus musculus in the Netherlands, we tested these rodents for mutations in codon 139 of the Vkorc1 gene. In addition, we collected data from pest controllers on their use of rodenticides and experience with rodenticide resistance.

resultsA total of 1801 rodent samples were collected throughout the country consisting of 1404 R. norvegicus and 397 M. musculus. In total, 15% of R. norvegicus [95% confidence interval (CI): 13-17%] and 38% of M. musculus (95% CI: 33-43%) carried a genetic mutation at codon 139 of the Vkorc1 gene.

conclusionThis study demonstrates genetic mutations at codon 139 of the Vkorc1 gene in M. musculus in the Netherlands. Resistance to anticoagulant rodenticides is present in R. norvegicus and M. musculus in multiple regions in the Netherlands. The results of this comprehensive study provide a baseline and facilitate trend analyses of Vkorc1 codon 139 mutations and evaluation of integrated pest management (IPM) strategies as these are enrolled in the Netherlands. © 2022 The Dutch Pest and Wildlife. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

RodenticidesAnimalsAnticoagulantsCodonDrug ResistanceMembrane ProteinsMiceMutationNetherlandsRatsVitamin K Epoxide ReductasesAnticoagulantsCodonMembrane ProteinsRodenticidesVitamin K Epoxide ReductasesVKORC1 protein, mouseVKORC1 protein, ratanticoagulanthouse mouseIPMMus musculusNorway ratpest managementRattus norvegicusrodent controlVkorc1

Identifiers

PMID36309944
PMCPMC10107327
OpenAlexW4307617191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.