ArticleAIDS and behavior2023
Intersecting Relationships of Psychosocial and Structural Syndemic Problems Among People with HIV in South Africa: Using Network Analysis to Identify Influential Problems.
Article in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Syndemics and clinical impact of HIV and mental health conditions among people living with HIV: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Gender-based violence syndemics in global health: A systematic review.Social science & medicine (1982) · 2025Pooled it
- Mlambe economic and relationship-strengthening intervention for alcohol use decreases violence and improves relationship quality in couples living with HIV in Malawi.Social science & medicine (1982) · 2024Trial
- Prior-Year Substance Use Disorders and Subsequent HIV Retention in Care Among Men Living with HIV Who Have Sex with Men.AIDS and behavior · 2026Article
- The Syndemic Effects of Food Insecurity, Depression, and Gender-Based Violence on HIV Treatment Outcomes Among People with HIV in Zimbabwe.AIDS and behavior · 2026Observational
- Syndemic convergence of mpox and HIV crisis in the Philippines: implications for integrated and responsive public health action.International journal for equity in health · 2026Article
- Using network analysis to elucidate the relationships among support systems, trauma and depressive symptoms, self-silencing, and risk of HIV viral non-suppression among black women living with HIV.Journal of behavioral medicine · 2025Article
- A systematic comparison of additive and interaction approaches to modeling the effects of syndemic problems on HIV outcomes in South Africa.Journal of behavioral medicine · 2024Article
- Mapping a psychosocial syndemic among methamphetamine-using sexual minority men living with HIV.Drug and alcohol review · 2024Article
- Prevalence and co-occurrence of symptoms of mental and substance use disorders among people with HIV age 40 and older in low- and middle-income countries: a cross-sectional study.Journal of the International AIDS Society · 2024Article
- Smartphone and Wearable Device-Based Digital Phenotyping to Understand Substance use and its Syndemics.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024Article
- Community health worker training to reduce mental health and substance use stigma towards patients who have disengaged from HIV/TB care in South Africa: protocol for a stepped wedge hybrid type II pilot implementation trial.Implementation science communications · 2024Article
- The Economic Burden of Chronic Diseases with Co-Occurring Depression and Alcohol Use Disorder for People in the Western Cape, South Africa.SSM. Mental health · 2023Article
- Children of a syndemic: co-occurring and mutually reinforcing adverse child health exposures in a prospective cohort of HIV-affected mother-infant dyads in Cape Town, South Africa.Journal of the International AIDS Society · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
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Abstract
In South Africa, little is known about interrelationships between syndemic problems among people with HIV (PWH). A better understanding of syndemic problems may yield important information regarding factors amenable to mitigation. We surveyed 194 PWH in Khayelitsha, outside of Cape Town, South Africa. We used network analysis to examine the frequency of 10 syndemic problems and their interrelationships. Syndemic problems among PWH in South Africa were common; 159 (82.8%) participants reported at least 2 co-occurring syndemic problems and 90 (46.9%) endorsed 4 or more. Network analysis revealed seven statistically significant associations. The most central problems were depression, substance use, and food insecurity. Three clusters of syndemics were identified: mood and violence; structural factors; and behavioral factors. Depression, substance use, and food insecurity commonly co-occur among PWH in sub-Saharan Africa and interfere with HIV outcomes. Network analysis can identify intervention targets to potentially improve HIV treatment outcomes.
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