Evidence map›Paper›PMID 36309763›Full record

ArticleCell & bioscience2022

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake.

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B Wheeler, Zhiping P Pang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 83 citations in OpenAlex.

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  10. Females are protected from semaglutide-induced muscle loss inbioRxiv : the preprint server for biology · 2026
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  12. GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Ishnoor Singh *The Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Le Wang *The Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. lw611@rwjms.rutgers.edu.
Baijuan XiaThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Ji LiuThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Azeddine TahiriThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Abdelfattah El OuaamariThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Michael B WheelerDepartment of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Zhiping P PangThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. pangzh@rwjms.rutgers.edu.ORCID http://orcid.org/0000-0002-6183-1233
Rutgers, The State University of New Jersey · USUniversity of Toronto · CA

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7M
Synaptic and circuit mechanisms of central GLP-1 signaling in energy balanceR01DK131452 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2022 to 2026
$2.4M
Sensory Neuromodulation of Pancreatic Beta CellsR01DK122167 · NIDDK · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI EL OUAAMARI, ABDELFATTAH · 2020 to 2024
$2.0M
NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK122167NIDDK NIH HHS R01DK122167NIDDK NIH HHS R01 DK131452NIDDK NIH HHS R01DK131452
6 · The paper itself

Abstract

backgroundCentral nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon 'Gcg' gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well understood.

resultsWe analyzed the distribution of GLP-1R-expressing neurons and axonal projections of NTS GLP-1-producing neurons in the mouse brain. GLP-1R neurons were found to be broadly distributed in the brain and specific forebrain regions, particularly the hypothalamus, including the arcuate nucleus of the hypothalamus (ARC), a brain region known to regulate energy homeostasis and feeding behavior, that receives dense NTS

conclusionsThese results highlight the importance of central GLP-1 signaling in the ARC that express GLP-1R that upon activation, regulate feeding behavior.

Indexed as

ChemogeneticsExendin-4FeedingGlucagon-like peptide-1Glucose toleranceHypothalamusPro-opiomelanocortin

Identifiers

PMID36309763
PMCPMC9618215
OpenAlexW4307841890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.