Evidence map›Paper›PMID 36309748›Full record

Trial reportReproductive biology and endocrinology : RB&E2022

Circulating Anti-Müllerian hormone in a cohort-study of women with severe obesity with and without polycystic ovary syndrome and the effect of a one-year weight loss intervention.

Josefin Kataoka, Ingrid Larsson, Eva Lindgren, Li Oskarson Kindstrand, Johanna Schmidt, Elisabet Stener-Victorin

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Reproductive biology and endocrinology : RB&E, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01319162 (To Estimate the Prevalence of PCOS in Obese Premenopausal Women and Elucidate How They Respond to a Weight Reduction Treatment Program), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01319162 completednot on this map

To Estimate the Prevalence of PCOS in Obese Premenopausal Women and Elucidate How They Respond to a Weight Reduction Treatment Program

TypeobservationalSponsorGöteborg UniversityRan2011 to 2017Enrolled300ConditionsPolycystic Ovary SyndromeArmsWeight reduction regimen
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Josefin KataokaInstitute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Box 430, 405 30, Gothenburg, Sweden.
Ingrid LarssonDepartment of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Eva LindgrenDepartment of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, B5, 171 77, Stockholm, Sweden.
Li Oskarson KindstrandDepartment of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, B5, 171 77, Stockholm, Sweden.
Johanna SchmidtInstitute of Clinical Sciences, Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, 416 85, Gothenburg, Sweden.
Elisabet Stener-VictorinDepartment of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, B5, 171 77, Stockholm, Sweden. elisabet.stener-victorin@ki.se.
Karolinska Institutet · SEUniversity of Gothenburg · SE

Funding

Diabetes Foundation: DIA2021-633• Distinguished Investigator Grant - Endocrinology and Metabolism, Novo Nordisk Foundation NNF22OC0072904Novo Nordisk Fonden NNF18OC0033992 and NNF19OC0056647Swedish federal government under the LUA/ALF agreement ALFGBG-429501Vetenskapsrådet 2018-02435
6 · The paper itself

Abstract

backgroundWomen with polycystic ovary syndrome (PCOS) have high circulating anti-Müllerian hormone (AMH) levels which is correlated with antral follicle count and polycystic ovarian morphology and negatively correlated with body mass index (BMI). Moreover, diet-induced weight loss in women with PCOS and overweight or obesity, reduce or normalize AMH-levels. There is, however, no previous study investigating the circulating AMH levels in women with severe obesity and how a structured diet-induced weight loss program affects circulating AMH levels in these women. Therefore, this study aims to investigate circulating AMH levels in a population of women with severe obesity (BMI ≥ 35 kg/m

methodsIn a prospective cohort-study, were 246 women with severe obesity were screened for PCOS diagnosis with the NIH-criteria, circulating AMH and anthropometry were measured at baseline and after a 12-month weight loss intervention with very low-energy diet (VLED).

resultsMean BMI was 39.9 ± 4.7 (PCOS), 39.6 ± 4.3 (non-PCOS) P = 0.960. Circulating AMH was higher in women with PCOS (5.47 ± 4.89 µg/L) compared with non-PCOS (2.66 ± 3.71 µg/L) P < 0.001 and was positively correlated with circulating total testosterone in both groups. Next, we performed ROC-analyses, and show that circulating AMH could not discriminate women with PCOS and severe obesity from non-PCOS women with severe obesity. Finally, a one-year weight reduction program does not affect circulating AMH levels despite significant weight loss neither in women with PCOS, nor without PCOS and severe obesity.

conclusionWomen with severe obesity and PCOS have elevated levels of circulating AMH compared to women without the syndrome. AMH-levels could not discriminate women with PCOS from non-PCOS because of low sensitivity and specificity. Significant weight loss was not associated with changes in circulating AMH levels, neither in women with, nor without PCOS and severe obesity. These results imply that in women with severe obesity, a greater weight loss may be needed to improve reproductive features, independent of PCOS diagnosis. TRIAL REGISTRATION NUMBER: Clinical trial.gov: NCT01319162.

Indexed as

Obesity, MorbidPolycystic Ovary SyndromeAnti-Mullerian HormoneFemaleHumansProspective StudiesTestosteroneAnti-Mullerian HormoneTestosteroneAnti-Müllerian hormonePolycystic ovary syndromeSevere obesityWeight loss

Identifiers

PMID36309748
PMCPMC9617381
OpenAlexW4307950805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.