ArticleRespiratory research2022
Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.
Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Combining computed tomography radiomics and clinical features to predict lymph node metastasis in patients with lung cancer.BMC medical imaging · 2026Article
- Habitat-based radiomics from contrast-enhanced CT and clinical data to predict lymph node metastasis in clinical N0 peripheral lung adenocarcinoma ≤ 3 cm.Scientific reports · 2025Article
- Non-small cell lung cancer in ever-smokers vs never-smokers.BMC medicine · 2025Article
- Clinical characteristics and prognosis of non-high-risk patients with incidental stage T1 lung cancer: A prospective cohort study.Clinical and experimental medicine · 2024Article
- Clinicopathological characteristics and prognosis of non-small cell lung cancer in Algeria: a single-center retrospective study.BMC cancer · 2024Article
- Squamous Cell Carcinoma in Never Smokers: An Insight into SMARCB1 Loss.International journal of molecular sciences · 2024Article
- Pulmonary mucinous adenocarcinoma: An overview of pathophysiology and advancements in treatment.Heliyon · 2024Review
- Predicting lymph node metastasis of clinical T1 non-small cell lung cancer: a brief review of possible methodologies and controversies.Frontiers in oncology · 2024Review
- Lung cancer in never smokers (LCINS): development of a UK national research strategy.BJC reports · 2023Review
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Authors and funding
22 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundLung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (NSCLC), we characterized lung cancer patients in China looking for demographic and clinical differences between the smoking and never-smoking subgroups.
methodsIn total, 891 patients with NSCLC, including 841 with adenocarcinoma and 50 with squamous cell carcinoma, were recruited in this study. Association of smoking status with demographic and clinical features of NSCLC was determined, and risk factors for lymph node metastasis and TNM stage were evaluated using Multivariate logistic regression analysis.
resultsIn patients with adenocarcinoma, never smokers showed a younger age at diagnosis (54.2 ± 12.7vs. 59.3 ± 9.4, p
conclusionThis study demonstrates that lung adenocarcinoma in never smokers significantly differ from those in smokers regarding both age at diagnosis and risk of lymph node metastasis, supporting the notion that they are distinct entries with different etiology and pathogenesis.
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