ArticleThe ultrasound journal2022
The CLOSED protocol to assess optic nerve sheath diameter using color-Doppler: a comparison study in a cohort of idiopathic normal pressure hydrocephalus patients.
Article in The ultrasound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06057155 (Correlation Between Intracranial Pressure and Optic Nerve Sheath Diameter Measured With CLOSED Bundle in Patients With Acute Brain Injury), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Intracranial Pressure and Optic Nerve Sheath Diameter Measured With CLOSED Bundle in Patients With Acute Brain Injury: Multicenter Observational Study
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Ultrasound measurement of the optic nerve and its sheath using the CLOSED protocol: comparison with MRI in a porcine in-vivo model.BMC veterinary research · 2026Article
- Effect of caudal block injection speed on optic nerve sheath diameter in pediatric surgeries: A prospective observational cohort study.Medicine · 2026Observational
- Ultrasound-measured optic nerve sheath diameter as a non-invasive tool for screening elevated-pressure from normal-pressure hydrocephalus: a cross-sectional study.Neurosurgical review · 2025Article
- Optic nerve sheath diameter measurement in healthy South Iranian adults from a cross-sectional ultrasonographic study.Scientific reports · 2025Article
- Optic nerve sheath diameters in nontraumatic brain injury: A scoping review and role in the intensive care unit.World journal of critical care medicine · 2024Article
- Prognostic Value of Optic Nerve Sheath Diameters after Acute Ischemic Stroke According to Slice Thickness on Computed Tomography.Diagnostics (Basel, Switzerland) · 2024Article
- Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort study.The ultrasound journal · 2023Article
- Response to Letter to Editor on "A Proposal for a New Protocol for Sonographic Assessment of the Optic Nerve Sheath Diameter: The CLOSED Protocol".Neurocritical care · 2023Article
- Optic Nerve Sheath Diameter: A Cross-Sectional Study of Ultrasonographic Measurement in Healthy Black South African Adults.Life (Basel, Switzerland) · 2023Article
- Evaluation of commercially available point-of-care ultrasound for automated optic nerve sheath measurement.The ultrasound journal · 2023Article
- Magnetic Resonance-Based Assessment of Optic Nerve Sheath Diameter: A Prospective Observational Cohort Study on Inter- and Intra-Rater Agreement.Journal of clinical medicine · 2023Article
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- Ultrasonographic measurement of the optic nerve sheath diameter to detect intracranial hypertension: an observational study.The ultrasound journal · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSonographic assessment of the optic nerve sheath diameter represents a promising non-invasive technique for estimation of the intracranial pressure. A wide inter-observer variability, along with a lack of a standardized protocol for the optic nerve sheath diameter measurements, could lead to over- or under-estimation. The present study was aimed at evaluating feasibility of color-Doppler for better delineating optic nerve sheath borders, comparing it to B-mode imaging, using the magnetic resonance measurements as a comparison.
methodsOptic nerve sheath diameters were evaluated using magnetic resonance by an expert radiologist in a cohort of patients with suspected idiopathic normal pressure hydrocephalus. Magnetic resonance findings were evaluated twice. In the first half of this cohort, optic nerve sheath diameters were measured using B-mode only, in the second half applying color-Doppler. Measurements obtained using these two techniques were compared to magnetic resonance imaging measurements. The Bland-Altman analysis and concordance correlation coefficient were computed to quantify the strength of agreement between the two magnetic resonance assessments. Box plots and average (± SD) were used to compare assessments by sonographic and magnetic resonance methods.
resultsFifty patients were included. MRI assessment showed a moderate concordance correlation coefficient. Optic nerve sheath diameters measured applying color-Doppler were lower (p < 0.001) and less scattered compared to B-mode assessment, which approached more to magnetic resonance measurements.
conclusionsIn this cohort of patients, magnetic resonance showed high intra-rater variability in optic nerve sheath diameter assessments. Optic nerve sheath diameter assessments using color-Doppler yielded lower and less scattered diameters compared to B-mode only.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.