Evidence map›Paper›PMID 36309587›Full record

ArticleCommunications biology2022

Loss of E-cadherin is causal to pathologic changes in chronic lung disease.

Baishakhi Ghosh, Jeffrey Loube, Shreeti Thapa, Hurley Ryan, Erin Capodanno, Daniel Chen, Carter Swaby, Si Chen, Saborny Mahmud, Mirit Girgis and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. AFrontiers in tuberculosis · 2026
    Article
  5. Article
  6. Review
  7. Localized Knockout of E-Cadherin in Subglottic Mucosa Increases Fibrosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. A Comprehensive Flow Cytometry Panel for Analysis of Idiopathic Subglottic Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024
    Article
  14. Review
  15. Article
  16. Epigenetic Reprogramming Drives Epithelial Disruption in Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 1 institution in 2 countries.

Baishakhi GhoshDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jeffrey LoubeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shreeti ThapaDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Hurley RyanDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Erin CapodannoJohns Hopkins University, Baltimore, MD, USA.
Daniel ChenJohns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-3168-2564
Carter SwabyJohns Hopkins University, Baltimore, MD, USA.
Si ChenDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Saborny MahmudDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mirit GirgisJohns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0993-5270
Kristine NishidaDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Linyan YingDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Pratulya Pragadaraju ChengalaDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ethan TiengJohns Hopkins University, Baltimore, MD, USA.
Michael BurnimDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ara WallyDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Debarshi BhowmikDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Michael ZaykanerDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Bonnie Yeung-LukDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Wayne MitznerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-1615-4090
Shyam BiswalDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Venkataramana K SidhayeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. vsidhay1@jhmi.edu.ORCID 0000-0002-4506-8549
Johns Hopkins University · US

Funding

Role of E-cadherin in modulating airway epithelial function and parenchymal remodelingR01HL151107 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2020 to 2023
$2.4M
Actin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
NHLBI NIH HHS R01 HL124099NHLBI NIH HHS R01 HL151107NIH HHS S10 OD016374U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HLR01-HL151107U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL124099
6 · The paper itself

Abstract

Epithelial cells line the lung mucosal surface and are the first line of defense against toxic exposures to environmental insults, and their integrity is critical to lung health. An early finding in the lung epithelium of patients with chronic obstructive pulmonary disease (COPD) is the loss of a key component of the adherens junction protein called E-cadherin. The cause of this decrease is not known and could be due to luminal insults or structural changes in the small airways. Irrespective, it is unknown whether the loss of E-cadherin is a marker or a driver of disease. Here we report that loss of E-cadherin is causal to the development of chronic lung disease. Using cell-type-specific promoters, we find that knockout of E-cadherin in alveolar epithelial type II but not type 1 cells in adult mouse models results in airspace enlargement. Furthermore, the knockout of E-cadherin in airway ciliated cells, but not club cells, increase airway hyperreactivity. We demonstrate that strategies to upregulate E-cadherin rescue monolayer integrity and serve as a potential therapeutic target.

Indexed as

CadherinsPulmonary Disease, Chronic ObstructiveAnimalsEpithelial CellsEpitheliumLungMiceCadherinsCdh1 protein, mouse

Identifiers

PMID36309587
PMCPMC9617938
OpenAlexW4307952887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.