ArticleSchizophrenia (Heidelberg, Germany)2022
Impaired dynamic functional brain properties and their relationship to symptoms in never treated first-episode patients with schizophrenia.
Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis.Molecular psychiatry · 2025Pooled it
- Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder.BMC medicine · 2024Pooled it
- Dynamic Co-Modulation (DyCoM): A Unified Operator Framework for Dynamic Connectivity in Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Multidimensional cortical morphological alterations in COPD using explainable machine learning.iScience · 2026Article
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Functional inertia reveals history-dependent organization of large-scale brain dynamics.Research square · 2026Article
- Unraveling the Individualized Shared and Distinct Dynamic Functional Connectivity in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome.CNS neuroscience & therapeutics · 2026Article
- Cortical morphometric inverse divergence in attention-deficit/hyperactivity disorder correlates with cell-type-specific, laminar-specific and developmental transcriptomic signatures.Psychological medicine · 2026Article
- Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder.European child & adolescent psychiatry · 2026Article
- Dynamic network dysregulation in post-stroke aphasia: analysis of dALFF and dynamic functional connectivity.BMC medical imaging · 2026Article
- NeuroMark-DyFICA: NeuroMark dynamic frequency-informed ICA with high-frequency spatial filtering for windowed fMRI analysis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.CNS neuroscience & therapeutics · 2026Article
- Mental time travel and insight in schizophrenia.Psychological medicine · 2025Review
- Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder.Psychological medicine · 2025Article
- Functional Inertia Index of Memory-Retaining Brain Dynamics: A Measure of Large-Scale Brain Adaptability.bioRxiv : the preprint server for biology · 2025Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder.Comprehensive psychoneuroendocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies of dynamic functional connectivity (dFC) and topology can provide novel insights into the neurophysiology of brain dysfunction in schizophrenia and its relation to core symptoms of psychosis. Limited investigations of these disturbances have been conducted with never-treated first-episode patients to avoid the confounds of treatment or chronic illness. Therefore, we recruited 95 acutely ill, first-episode, never-treated patients with schizophrenia and examined brain dFC patterns relative to healthy controls using resting-state functional magnetic resonance imaging and a sliding-window approach. We compared the dynamic attributes at the group level and found patients spent more time in a hypoconnected state and correspondingly less time in a hyperconnected state. Patients demonstrated decreased dynamics of nodal efficiency and eigenvector centrality (EC) in the right medial prefrontal cortex, which was associated with psychosis severity reflected in Positive and Negative Syndrome Scale ratings. We also observed increased dynamics of EC in temporal and sensorimotor regions. These findings were supported by validation analysis. To supplement the group comparison analyses, a support vector classifier was used to identify the dynamic attributes that best distinguished patients from controls at the individual level. Selected features for case-control classification were highly coincident with the properties having significant between-group differences. Our findings provide novel neuroimaging evidence about dynamic characteristics of brain physiology in acute schizophrenia. The clinically relevant atypical pattern of dynamic shifting between brain states in schizophrenia may represent a critical aspect of illness pathophysiology underpinning its defining cognitive, behavioral, and affective features.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.