Evidence map›Paper›PMID 36309370›Full record

ArticleIn vivo (Athens, Greece)

Association of

Liang-Chun Shih, Chia-Wen Tsai, Tzu-Chieh Lin, Yun-Chi Wang, Jie-Long He, Che-Lun Hsu, Te-Chun Hsia, Fuu-Jen Tsai, Jai-Sing Yang, Yuan-Man Hsu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Liang-Chun Shih *Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chia-Wen Tsai *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Tzu-Chieh Lin *Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Yun-Chi WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Jie-Long HeDepartment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan, R.O.C.
Che-Lun HsuDepartment of Otorhinolaryngology, Asia University Hospital, Taichung, Taiwan, R.O.C.
Te-Chun HsiaTerry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Fuu-Jen TsaiDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Jai-Sing YangDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Yuan-Man HsuDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
DA-Tian Bau *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com.
Wen-Shin Chang *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; halittlemelon@hotmail.com.
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe over-expression of enhancer of zeste homolog 2 (EZH2) protein is found in oral cancer tissues. However, the genetic role of the enhancer of EZH2 in the etiology of oral cancer is unknown. The aim of this study was to evaluate the association of EZH2 genotypes with oral cancer risk among Taiwanese. MATERIALS AND

methodsThree polymorphic variants of EZH2, rs887569 (C to T), rs41277434 (A to C), and rs3757441 (T to C), were analyzed regarding their association with oral cancer risk among 958 oral cancer patients and the same number of healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, the interaction of EZH2 rs887569, rs41277434, and rs3757441 genotypes with personal behaviors such as smoking, alcohol drinking, and betel quid chewing were also examined.

resultsThe EZH2 genotypes rs887569, rs41277434, and rs3757441, were not significantly associated with oral cancer risk (p for trend=0.1735, 0.5658, and 0.4606, respectively). The analysis of allelic frequency distribution also supported the findings that the variant alleles at EZH2 rs887569, rs41277434, and rs3757441 may not serve as determinants of oral cancer risk (all p>0.05). There was no interaction between EZH2 rs887569, rs41277434, or rs3757441 genotypes with personal smoking, alcohol drinking or betel quid chewing behaviors.

conclusionEZH2 genotypes cannot predict oral cancer risk in Taiwan.

Indexed as

Enhancer of Zeste Homolog 2 ProteinMouth NeoplasmsCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideRisk FactorsTaiwanEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanEnhancer of zeste homolog 2 (EZH2)genotypeoral cancersingle nucleotide polymorphismTaiwan

Identifiers

PMID36309370
PMCPMC9677796
OpenAlexW4307840285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.