Evidence map›Paper›PMID 36309348›Full record

ArticleIn vivo (Athens, Greece)

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database.

Cristian Nicolae Sava, Teodora-Maria Bodog, Larisa Roxana Niulas, Alin Remus Iuhas, Cristian Phillip Marinau, Nicoleta Negrut, Andreea Bianca Balmos, Bianca Pasca, Nadinne Alexandra Roman, Carmen Delia Nistor-Cseppento

Abstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Creatine Kinase as a Predictor of Disease Severity in Children with COVID-19.Medical journal of the Islamic Republic of Iran · 2025
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  5. Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristian Nicolae Sava *Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Teodora-Maria Bodog *Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Larisa Roxana NiulasDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Alin Remus IuhasDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Cristian Phillip MarinauDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Nicoleta NegrutDepartment of Psycho-neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; lnm_n10@yahoo.com.
Andreea Bianca Balmos *Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; andreeabalmos@gmail.com.
Bianca Pasca *Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Nadinne Alexandra RomanFaculty of Medicine, Transilvania University of Brasov, Brasov, Romania.
Carmen Delia Nistor-CseppentoDepartment of Psycho-neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of the new variants of the virus, clinical manifestations have been reported in the pediatric population, some with severe evolution. The aim of this study was to identify the laboratory parameters necessary to establish an effective therapy. PATIENTS AND

methodsIn the period from August 2020 to September 2021, 234 pediatric patients met the inclusion criteria and were selected for the study. After confirming the COVID-19 diagnosis, laboratory parameters were analyzed and compared to the severity of the illness.

resultsThrombocytopenia (p<0.001), leukocytosis (p<0.001), and lymphopenia (p<0.001) correlated with the severity of the disease. Also, D-dimer values were closely monitored due to the high association of this parameter with an unsatisfactory prognosis and a severe form of the disease.

conclusionThe D-dimer values and complete blood count are useful parameters in COVID-19 evaluation in children.

Indexed as

COVID-19ThrombocytopeniaBiomarkersChildCOVID-19 TestingHumansRetrospective StudiesSARS-CoV-2BiomarkersCOVID-19D-dimersleukocytosispediatricSARS-CoV-2

Identifiers

PMID36309348
PMCPMC9677791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.