Evidence map›Paper›PMID 36309163›Full record

ArticleNeurotoxicology2022

Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.

Paulo B de Freitas, Sandra M S F Freitas, Janina M Prado-Rico, Mechelle M Lewis, Guangwei Du, Jeff D Yanosky, Xuemei Huang, Mark L Latash

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Paulo B de FreitasInterdisciplinary Graduate Program in Health Science, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil.
Sandra M S F FreitasGraduate Program in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.
Janina M Prado-RicoDepartment of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA.
Mechelle M LewisDepartment of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Pharmacology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA.
Guangwei DuDepartment of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA.
Jeff D YanoskyDepartment of Public Health Science, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Xuemei HuangDepartment of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Pharmacology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Radiology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. Electronic address: Xuemei@psu.edu.
Mark L LatashDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, USA. Electronic address: mll11@psu.edu.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · USUniversidade Cidade de São Paulo · BRUniversidade Cruzeiro do Sul · BR

Funding

Regional Brain Manganese Accumulation and Functional Consequences in WeldersR01ES019672 · NIEHS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2011 to 2021
$5.9M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
Structural MRI marker(s) of Parkinson's Disease's ProgressionR01NS060722 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2009 to 2013
$2.9M
Indices of Motor Synergies as Early Biomarkers of Parkinson's DiseaseR21NS095873 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, XUEMEI, LATASH, MARK L · 2016 to 2017
$423k
NIEHS NIH HHS R01 ES019672NINDS NIH HHS R01 NS060722NINDS NIH HHS R21 NS095873NINDS NIH HHS U01 NS082151
6 · The paper itself

Abstract

Motor synergies, i.e., neural mechanisms that organize multiple motor elements to ensure stability of actions, are affected by several neurological condition. Asymptomatic welders showed impaired synergy controlling the stability of multi-finger action compared to non-welders and this impairment was associated with microstructural damage in the globus pallidus. We further explored the effect of welding-related metal exposure on multi-finger synergy and extended our investigation to posture-stabilizing synergy during a standing task. Occupational, MRI, and performance-stabilizing synergies during multi-finger accurate force production and load releasing while standing were obtained from 29 welders and 19 age- and sex-matched controls. R2* and R1 relaxation rate values were used to estimate brain iron and manganese content, respectively, and diffusion tensor imaging was used to reflect brain microstructural integrity. Associations of brain MRI (caudate, putamen, globus pallidus, and red nucleus), and motor synergy were explored by group status. The results revealed that welders had higher R2* values in the caudate (p = 0.03), putamen (p = 0.01), and red nucleus (p = 0.08, trend) than controls. No group effect was revealed on multi-finger synergy index during steady-state phase of action (ΔV

Indexed as

Air Pollutants, OccupationalOccupational ExposureWeldingDiffusion Tensor ImagingHumansManganeseMetalsPhysical ExertionAir Pollutants, OccupationalManganeseMetalsBasal gangliaCerebellumCoordinationMotor synergyMRIOccupational exposure

Identifiers

PMID36309163
PMCPMC10398836
OpenAlexW4307304200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.